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A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers.
Raja SM, Guptill JT, Mack M, Peterson M, Byard S, Twieg R, Jordan L, Rich N, Castledine R, Bourne S, Wilmshurst M, Oxendine S, Avula SGC, Zuleta H, Quigley P, Lawson S, McQuaker SJ, Ahmadkhaniha R, Appelbaum LG, Kowalski K, Barksdale CT, Gufford BT, Awan A, Sancho AR, Moore MC, Berrada K, Cogan GB, DeLaRosa J, Radcliffe J, Pao M, Kennedy M, Lawrence Q, Goldfeder L, Amanfo L, Zanos P, Gilbert JR, Morris PJ, Moaddel R, Gould TD, Zarate CA Jr, Thomas CJ. Raja SM, et al. Among authors: castledine r. Clin Pharmacol Ther. 2024 Nov;116(5):1314-1324. doi: 10.1002/cpt.3391. Epub 2024 Jul 25. Clin Pharmacol Ther. 2024. PMID: 39054770 Clinical Trial.
High Yielding Continuous-Flow Synthesis of Norketamine.
Hernando MV, Moore JC, Howie RA, Castledine RA, Bourne SL, Jenkins GN, Licence P, Poliakoff M, George MW. Hernando MV, et al. Among authors: castledine ra. Org Process Res Dev. 2022 Apr 15;26(4):1145-1151. doi: 10.1021/acs.oprd.1c00407. Epub 2022 Mar 26. Org Process Res Dev. 2022. PMID: 35573033 Free PMC article. Review.