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Page 1
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
Mackman RL, Steadman VA, Dean DK, Jansa P, Poullennec KG, Appleby T, Austin C, Blakemore CA, Cai R, Cannizzaro C, Chin G, Chiva JC, Dunbar NA, Fliri H, Highton AJ, Hui H, Ji M, Jin H, Karki K, Keats AJ, Lazarides L, Lee YJ, Liclican A, Mish M, Murray B, Pettit SB, Pyun P, Sangi M, Santos R, Sanvoisin J, Schmitz U, Schrier A, Siegel D, Sperandio D, Stepan G, Tian Y, Watt GM, Yang H, Schultz BE. Mackman RL, et al. Among authors: fliri h. J Med Chem. 2018 Nov 8;61(21):9473-9499. doi: 10.1021/acs.jmedchem.8b00802. Epub 2018 Aug 22. J Med Chem. 2018. PMID: 30074795
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
Steadman VA, Pettit SB, Poullennec KG, Lazarides L, Keats AJ, Dean DK, Stanway SJ, Austin CA, Sanvoisin JA, Watt GM, Fliri HG, Liclican AC, Jin D, Wong MH, Leavitt SA, Lee YJ, Tian Y, Frey CR, Appleby TC, Schmitz U, Jansa P, Mackman RL, Schultz BE. Steadman VA, et al. Among authors: fliri hg. J Med Chem. 2017 Feb 9;60(3):1000-1017. doi: 10.1021/acs.jmedchem.6b01329. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28075591
Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency.
Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E. Ehinger JK, et al. Among authors: fliri h. Nat Commun. 2016 Aug 9;7:12317. doi: 10.1038/ncomms12317. Nat Commun. 2016. PMID: 27502960 Free PMC article.
Cellular basis for bimatoprost effects on human conventional outflow.
Stamer WD, Piwnica D, Jolas T, Carling RW, Cornell CL, Fliri H, Martos J, Pettit SN, Wang JW, Woodward DF. Stamer WD, et al. Among authors: fliri h. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5176-81. doi: 10.1167/iovs.09-4955. Epub 2010 Apr 30. Invest Ophthalmol Vis Sci. 2010. PMID: 20435598 Free PMC article.
Bimatoprost, prostamide activity, and conventional drainage.
Wan Z, Woodward DF, Cornell CL, Fliri HG, Martos JL, Pettit SN, Wang JW, Kharlamb AB, Wheeler LA, Garst ME, Landsverk KJ, Struble CS, Stamer WD. Wan Z, et al. Among authors: fliri hg. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4107-15. doi: 10.1167/iovs.07-0080. Invest Ophthalmol Vis Sci. 2007. PMID: 17724194 Free PMC article.
Cyclosporins. Structure-activity relationships.
Fliri H, Baumann G, Enz A, Kallen J, Luyten M, Mikol V, Movva R, Quesniaux V, Schreier M, Walkinshaw M, et al. Fliri H, et al. Ann N Y Acad Sci. 1993 Nov 30;696:47-53. Ann N Y Acad Sci. 1993. PMID: 8109856 Review.