Yen CW - Search Results

1

Physicochemical and structural insights into lyophilized mRNA-LNP from lyoprotectant and buffer screenings.

Fan Y, Rigas D, Kim LJ, Chang FP, Zang N, McKee K, Kemball CC, Yu Z, Winkler P, Su WC, Jessen P, Hura GL, Chen T, Koenig SG, Nagapudi K, Leung D, Yen CW. Fan Y, et al. Among authors: yen cw. J Control Release. 2024 Sep;373:727-737. doi: 10.1016/j.jconrel.2024.07.052. Epub 2024 Aug 2. J Control Release. 2024. PMID: 39059500

2

Automated high-throughput preparation and characterization of oligonucleotide-loaded lipid nanoparticles.

Fan Y, Yen CW, Lin HC, Hou W, Estevez A, Sarode A, Goyon A, Bian J, Lin J, Koenig SG, Leung D, Nagapudi K, Zhang K. Fan Y, et al. Among authors: yen cw. Int J Pharm. 2021 Apr 15;599:120392. doi: 10.1016/j.ijpharm.2021.120392. Epub 2021 Feb 25. Int J Pharm. 2021. PMID: 33639228

3

Discovery of a dual pathway aggregation mechanism for a therapeutic constrained peptide.

Chen T, Tang S, Hecht ES, Yen CW, Andersen N, Chin S, Cadang L, Roper B, Estevez A, Rohou A, Chang D, Dai L, Liu P, Al-Sayah M, Nagapudi K, Lin F, Famili A, Hu C, Kuhn R, Stella C, Crittenden CM, Gruenhagen JA, Venkatramani C, Hannoush RN, Leung D, Vandlen R, Yehl P. Chen T, et al. Among authors: yen cw. J Pharm Sci. 2021 Jun;110(6):2362-2371. doi: 10.1016/j.xphs.2020.12.041. Epub 2021 Feb 27. J Pharm Sci. 2021. PMID: 33652014

4

Impact of surfactant selection and incorporation on in situ nanoparticle formation from amorphous solid dispersions.

Yen CW, Kuhn R, Hu C, Zhang W, Chiang PC, Chen JZ, Hau J, Estevez A, Nagapudi K, Leung DH. Yen CW, et al. Int J Pharm. 2021 Sep 25;607:120980. doi: 10.1016/j.ijpharm.2021.120980. Epub 2021 Aug 8. Int J Pharm. 2021. PMID: 34371147

5

A Systematic Approach for Liposome and Lipodisk Preclinical Formulation Development by Microfluidic Technology.

Levy ES, Yu J, Estevez A, Mao J, Liu L, Torres E, Leung D, Yen CW. Levy ES, et al. Among authors: yen cw. AAPS J. 2021 Oct 14;23(6):111. doi: 10.1208/s12248-021-00651-4. AAPS J. 2021. PMID: 34651233 Free PMC article.

6

Optimization of Spray-Drying Parameters for Formulation Development at Preclinical Scale.

Nespi M, Kuhn R, Yen CW, Lubach JW, Leung D. Nespi M, et al. Among authors: yen cw. AAPS PharmSciTech. 2021 Dec 20;23(1):28. doi: 10.1208/s12249-021-02160-1. AAPS PharmSciTech. 2021. PMID: 34931259

7

An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.

Guo Y, Ji S, Wang W, Wong S, Yen CW, Hu C, Leung DH, Plise E, Zhang S, Zhang C, Anene UA, Zhang D, Cunningham CN, Khojasteh SC, Su D. Guo Y, et al. Among authors: yen cw. Anal Chem. 2022 Feb 1;94(4):2032-2041. doi: 10.1021/acs.analchem.1c04008. Epub 2022 Jan 18. Anal Chem. 2022. PMID: 35041378

8

Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing.

Sarode A, Fan Y, Byrnes AE, Hammel M, Hura GL, Fu Y, Kou P, Hu C, Hinz FI, Roberts J, Koenig SG, Nagapudi K, Hoogenraad CC, Chen T, Leung D, Yen CW. Sarode A, et al. Among authors: yen cw. Nanoscale Adv. 2022 Feb 4;4(9):2107-2123. doi: 10.1039/d1na00712b. eCollection 2022 May 3. Nanoscale Adv. 2022. PMID: 36133441 Free PMC article.

9

Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations.

Pratsinis A, Fan Y, Portmann M, Hammel M, Kou P, Sarode A, Ringler P, Kovacik L, Lauer ME, Lamerz J, Hura GL, Yen CW, Keller M. Pratsinis A, et al. Among authors: yen cw. Int J Pharm. 2023 Apr 25;637:122874. doi: 10.1016/j.ijpharm.2023.122874. Epub 2023 Mar 21. Int J Pharm. 2023. PMID: 36948476

10

Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering.

Hammel M, Fan Y, Sarode A, Byrnes AE, Zang N, Kou P, Nagapudi K, Leung D, Hoogenraad CC, Chen T, Yen CW, Hura GL. Hammel M, et al. Among authors: yen cw. ACS Nano. 2023 Jun 27;17(12):11454-11465. doi: 10.1021/acsnano.3c01186. Epub 2023 Jun 6. ACS Nano. 2023. PMID: 37279108 Free PMC article.

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