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Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Brandon EF, Bosch TM, Deenen MJ, Levink R, van der Wal E, van Meerveld JB, Bijl M, Beijnen JH, Schellens JH, Meijerman I. Brandon EF, et al. Among authors: deenen mj. Toxicol Appl Pharmacol. 2006 Feb 15;211(1):1-10. doi: 10.1016/j.taap.2005.05.004. Epub 2005 Jun 21. Toxicol Appl Pharmacol. 2006. PMID: 15975613
Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.
van den Wildenberg SAH, Streng AS, van den Broek R, Broeren MAC, Deenen MJ, van Dongen JLJ, Hanrath MA, Lapré C, Brunsveld L, Scharnhorst V, van de Kerkhof D. van den Wildenberg SAH, et al. Among authors: deenen mj. J Pharm Biomed Anal. 2022 Nov 30;221:115027. doi: 10.1016/j.jpba.2022.115027. Epub 2022 Sep 1. J Pharm Biomed Anal. 2022. PMID: 36099723 Free article.
Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers.
Jacobs BA, Deenen MJ, Pluim D, van Hasselt JG, Krähenbühl MD, van Geel RM, de Vries N, Rosing H, Meulendijks D, Burylo AM, Cats A, Beijnen JH, Huitema AD, Schellens JH. Jacobs BA, et al. Among authors: deenen mj. Br J Clin Pharmacol. 2016 Sep;82(3):706-16. doi: 10.1111/bcp.13007. Epub 2016 Jun 3. Br J Clin Pharmacol. 2016. PMID: 27161955 Free PMC article.
70 results