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A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway.
Yang MH, Basappa B, Deveshegowda SN, Ravish A, Mohan A, Nagaraja O, Madegowda M, Rangappa KS, Deivasigamani A, Pandey V, Lobie PE, Hui KM, Sethi G, Ahn KS. Yang MH, et al. Among authors: ahn ks. J Adv Res. 2024 Jul 25:S2090-1232(24)00305-9. doi: 10.1016/j.jare.2024.07.022. Online ahead of print. J Adv Res. 2024. PMID: 39067696 Free article.
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB. Sandur SK, et al. Among authors: ahn ks. J Biol Chem. 2006 Jun 23;281(25):17023-17033. doi: 10.1074/jbc.M601595200. Epub 2006 Apr 19. J Biol Chem. 2006. PMID: 16624823 Free article.
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Shishodia S, Sethi G, Ahn KS, Aggarwal BB. Shishodia S, et al. Among authors: ahn ks. Biochem Pharmacol. 2007 Jun 30;74(1):118-30. doi: 10.1016/j.bcp.2007.03.026. Epub 2007 Mar 30. Biochem Pharmacol. 2007. PMID: 17475222 Free PMC article.
845 results