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Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor.
Kooiker K, Gan QF, Yu M, Sa N, Mohran S, Cheng Y, Flint G, Neys S, Gao C, Nissen D, McMillen T, Asencio A, Ma W, Irving TC, Moussavi-Harami F, Regnier M. Kooiker K, et al. Among authors: gao c. J Gen Physiol. 2024 Oct 7;156(10):e202313503. doi: 10.1085/jgp.202313503. Epub 2024 Jul 31. J Gen Physiol. 2024. PMID: 39083045
The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.
Ma W, Jani VP, Song T, Gao C, Gong H, Sadayappan S, Kass DA, Irving TC. Ma W, et al. Among authors: gao c. bioRxiv [Preprint]. 2023 Oct 20:2023.10.18.562891. doi: 10.1101/2023.10.18.562891. bioRxiv. 2023. Update in: PNAS Nexus. 2024 Jan 30;3(2):pgae039. doi: 10.1093/pnasnexus/pgae039. PMID: 37904972 Free PMC article. Updated. Preprint.
Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle.
Kooiker KB, Mohran S, Turner KL, Ma W, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Martinson A, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, Irving TC, Geeves MA, Tanner BCW, Regnier M, Davis J, Moussavi-Harami F. Kooiker KB, et al. Among authors: gao c. bioRxiv [Preprint]. 2023 Feb 3:2023.01.31.526380. doi: 10.1101/2023.01.31.526380. bioRxiv. 2023. Update in: Circ Res. 2023 Aug 18;133(5):430-443. doi: 10.1161/CIRCRESAHA.123.322629. PMID: 36778318 Free PMC article. Updated. Preprint.
1-Year Clinical Outcomes and the Impact of Procedural Configurations in Left Atrial Appendage Occlusion Patients.
Gao C, Su F, Liu J, Zhang T, Ning Z, Yang B, Chu H, He B, Zhang J, Zhou L, Li Y, Zhang Y, Hu H, Xu Y, Zeng J, Guo J, Su X, Ruan ZB, Liu H, Wang P, Garg S, Soliman O, Holmes DR Jr, Serruys PW, Tao L; RECORD Investigators. Gao C, et al. JACC Asia. 2024 Oct 1;4(10):777-790. doi: 10.1016/j.jacasi.2024.07.013. eCollection 2024 Oct. JACC Asia. 2024. PMID: 39553900 Free PMC article.
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