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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP. Leyte-Vidal A, et al. Among authors: bahar i. Leukemia. 2024 Sep;38(9):2046-2050. doi: 10.1038/s41375-024-02353-0. Epub 2024 Jul 31. Leukemia. 2024. PMID: 39085402 Free PMC article. No abstract available.
Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.
Zhu Y, Banerjee A, Xie P, Ivanov AA, Uddin A, Jiao Q, Chi JJ, Zeng L, Lee JY, Xue Y, Lu X, Cristofanilli M, Gradishar WJ, Henry CJ, Gillespie TW, Bhave MA, Kalinsky K, Fu H, Bahar I, Zhang B, Wan Y. Zhu Y, et al. Among authors: bahar i. J Clin Invest. 2024 Mar 26;134(10):e176390. doi: 10.1172/JCI176390. J Clin Invest. 2024. PMID: 38530357 Free PMC article.
Structural basis of CMKLR1 signaling induced by chemerin9.
Zhang X, Weiß T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C. Zhang X, et al. Among authors: bahar i. bioRxiv [Preprint]. 2023 Jun 10:2023.06.09.544295. doi: 10.1101/2023.06.09.544295. bioRxiv. 2023. PMID: 37333145 Free PMC article. Preprint.
Influence of Point Mutations on PR65 Conformational Adaptability: Insights from Nanoaperture Optical Tweezer Experiments and Molecular Simulations.
Bahar I, Banerjee A, Mathew S, Naqvi M, Yilmaz S, Zachoropoulou M, Doruker P, Kumita J, Yang SH, Gur M, Itzhaki L, Gordon R. Bahar I, et al. Res Sq [Preprint]. 2023 Nov 16:rs.3.rs-3599809. doi: 10.21203/rs.3.rs-3599809/v1. Res Sq. 2023. Update in: Sci Adv. 2024 May 31;10(22):eadn2208. doi: 10.1126/sciadv.adn2208. PMID: 38014259 Free PMC article. Updated. Preprint.
472 results