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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP. Leyte-Vidal A, et al. Among authors: outhwaite ir. Leukemia. 2024 Sep;38(9):2046-2050. doi: 10.1038/s41375-024-02353-0. Epub 2024 Jul 31. Leukemia. 2024. PMID: 39085402 Free PMC article. No abstract available.
Allosteric regulation and inhibition of protein kinases.
Mingione VR, Paung Y, Outhwaite IR, Seeliger MA. Mingione VR, et al. Among authors: outhwaite ir. Biochem Soc Trans. 2023 Feb 27;51(1):373-385. doi: 10.1042/BST20220940. Biochem Soc Trans. 2023. PMID: 36794774 Free PMC article. Review.
Discovery and molecular basis of subtype-selective cyclophilin inhibitors.
Peterson AA, Rangwala AM, Thakur MK, Ward PS, Hung C, Outhwaite IR, Chan AI, Usanov DL, Mootha VK, Seeliger MA, Liu DR. Peterson AA, et al. Among authors: outhwaite ir. Nat Chem Biol. 2022 Nov;18(11):1184-1195. doi: 10.1038/s41589-022-01116-1. Epub 2022 Sep 26. Nat Chem Biol. 2022. PMID: 36163383 Free PMC article.
Motivation to Impact: Medical Student Volunteerism in the COVID 19 Pandemic.
Phillips HE, Jennings RB, Outhwaite IR, Grosser S, Chandra M, Ende V, Post SG. Phillips HE, et al. Among authors: outhwaite ir. Med Sci Educ. 2022 Sep 19;32(5):1149-1157. doi: 10.1007/s40670-022-01639-1. eCollection 2022 Oct. Med Sci Educ. 2022. PMID: 36160291 Free PMC article.