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Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.
MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O'Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL Jr, Robbins N, Nodwell J, Whitesell L, Cowen LE. MacAlpine J, et al. Among authors: andes dr. Nat Commun. 2024 Aug 1;15(1):6440. doi: 10.1038/s41467-024-50740-z. Nat Commun. 2024. PMID: 39090082 Free PMC article. No abstract available.
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Ušaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota T, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE. Iyer KR, et al. Among authors: andes dr. Cell Chem Biol. 2023 Jul 20;30(7):795-810.e8. doi: 10.1016/j.chembiol.2023.06.005. Epub 2023 Jun 26. Cell Chem Biol. 2023. PMID: 37369212 Free PMC article.
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and oral commensalism.
Glazier VE, Kramara J, Ollinger T, Solis NV, Zarnowski R, Wakade RS, Kim M-J, Weigel GJ, Liang S-H, Bennett RJ, Wellington M, Andes DR, Stamnes MA, Filler SG, Krysan DJ. Glazier VE, et al. Among authors: andes dr. mBio. 2023 Oct 31;14(5):e0152123. doi: 10.1128/mbio.01521-23. Epub 2023 Sep 22. mBio. 2023. PMID: 37737633 Free PMC article.
Biofilm-associated metabolism via ERG251 in Candida albicans.
Xiong L, Pereira De Sa N, Zarnowski R, Huang MY, Mota Fernandes C, Lanni F, Andes DR, Del Poeta M, Mitchell AP. Xiong L, et al. Among authors: andes dr. PLoS Pathog. 2024 May 13;20(5):e1012225. doi: 10.1371/journal.ppat.1012225. eCollection 2024 May. PLoS Pathog. 2024. PMID: 38739655 Free PMC article.
Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. Among authors: andes dr. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24 PMID: 39257751 Free PMC article. Updated. Preprint.
212 results