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Structures of TGF-β with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling.
Wieteska Ł, Taylor AB, Punch E, Coleman JA, Conway IO, Lin YF, Byeon CH, Hinck CS, Krzysiak T, Ishima R, López-Casillas F, Cherepanov P, Bernard DJ, Hill CS, Hinck AP. Wieteska Ł, et al. Among authors: krzysiak t. bioRxiv [Preprint]. 2024 Jul 22:2024.07.19.604101. doi: 10.1101/2024.07.19.604101. bioRxiv. 2024. PMID: 39091787 Free PMC article. Preprint.
TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. Henen MA, et al. Among authors: krzysiak tc. J Biol Chem. 2019 Mar 1;294(9):3065-3080. doi: 10.1074/jbc.RA118.005210. Epub 2018 Dec 31. J Biol Chem. 2019. PMID: 30598510 Free PMC article.
Correction to Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling.
Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Villarreal MM, et al. Among authors: krzysiak tc. Biochemistry. 2017 Jul 18;56(28):3689. doi: 10.1021/acs.biochem.7b00566. Epub 2017 Jul 5. Biochemistry. 2017. PMID: 28677957 Free PMC article. No abstract available.
Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling.
Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, Krzysiak TC, Henen MA, Pakhomova O, Mendoza V, O'Connor-McCourt MD, Lafer EM, López-Casillas F, Hinck AP. Villarreal MM, et al. Among authors: krzysiak tc. Biochemistry. 2016 Dec 13;55(49):6880-6896. doi: 10.1021/acs.biochem.6b00566. Epub 2016 Dec 2. Biochemistry. 2016. PMID: 27951653 Free PMC article.
Transmission electron microscopy for the evaluation and optimization of crystal growth.
Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G. Stevenson HP, et al. Among authors: krzysiak t. Acta Crystallogr D Struct Biol. 2016 May;72(Pt 5):603-15. doi: 10.1107/S2059798316001546. Epub 2016 Apr 26. Acta Crystallogr D Struct Biol. 2016. PMID: 27139624 Free PMC article.
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