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4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses.
Puxeddu M, Donalisio M, Bugert JJ, Corona A, Cocomazzi P, Milani M, Hucke F, Arduino I, Esposito F, Moretti P, Ortore MG, Nalli M, Manetto S, Mazzoccanti G, Bigogno C, Dondio G, Sciò P, Coluccia A, Fracella M, Antonelli G, Lembo D, Tramontano E, Silvestri R, Mastrangelo E, La Regina G. Puxeddu M, et al. ACS Infect Dis. 2024 Sep 13;10(9):3158-3175. doi: 10.1021/acsinfecdis.4c00108. Epub 2024 Aug 3. ACS Infect Dis. 2024. PMID: 39096289
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.
Puxeddu M, Shen H, Bai R, Coluccia A, Nalli M, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Orlando V, Biagioni S, Mazzoni C, Coluccia AML, Hamel E, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Eur J Med Chem. 2020 Jan 1;185:111828. doi: 10.1016/j.ejmech.2019.111828. Epub 2019 Nov 2. Eur J Med Chem. 2020. PMID: 31727471
Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage.
Coluccia A, Puxeddu M, Nalli M, Wei CK, Wu YH, Mastrangelo E, Elamin T, Tarantino D, Bugert JJ, Schreiner B, Nolte J, Schwarze F, La Regina G, Lee JC, Silvestri R. Coluccia A, et al. Among authors: puxeddu m. ACS Med Chem Lett. 2020 Jan 15;11(10):1869-1874. doi: 10.1021/acsmedchemlett.9b00405. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062166 Free PMC article.
Targeting the Interaction between the SH3 Domain of Grb2 and Gab2.
Malagrinò F, Coluccia A, Bufano M, Regina G, Puxeddu M, Toto A, Visconti L, Paone A, Magnifico MC, Troilo F, Cutruzzolà F, Silvestri R, Gianni S. Malagrinò F, et al. Among authors: puxeddu m. Cells. 2020 Nov 7;9(11):2435. doi: 10.3390/cells9112435. Cells. 2020. PMID: 33171874 Free PMC article.
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme.
Daniele S, La Pietra V, Piccarducci R, Pietrobono D, Cavallini C, D'Amore VM, Cerofolini L, Giuntini S, Russomanno P, Puxeddu M, Nalli M, Pedrini M, Fragai M, Luchinat C, Novellino E, Taliani S, La Regina G, Silvestri R, Martini C, Marinelli L. Daniele S, et al. Among authors: puxeddu m. Eur J Pharmacol. 2021 Apr 15;897:173936. doi: 10.1016/j.ejphar.2021.173936. Epub 2021 Feb 10. Eur J Pharmacol. 2021. PMID: 33581134
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
Puxeddu M, Shen H, Bai R, Coluccia A, Bufano M, Nalli M, Sebastiani J, Brancaccio D, Da Pozzo E, Tremolanti C, Martini C, Orlando V, Biagioni S, Sinicropi MS, Ceramella J, Iacopetta D, Coluccia AML, Hamel E, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Eur J Med Chem. 2021 Oct 5;221:113532. doi: 10.1016/j.ejmech.2021.113532. Epub 2021 May 5. Eur J Med Chem. 2021. PMID: 34052717
Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance.
Van Dycke J, Puxeddu M, La Regina G, Mastrangelo E, Tarantino D, Rymenants J, Sebastiani J, Nalli M, Matthijnssens J, Neyts J, Silvestri R, Rocha-Pereira J. Van Dycke J, et al. Among authors: puxeddu m. Pharmaceuticals (Basel). 2021 Sep 30;14(10):1006. doi: 10.3390/ph14101006. Pharmaceuticals (Basel). 2021. PMID: 34681230 Free PMC article.
Emerging Therapeutic Agents for Colorectal Cancer.
Nalli M, Puxeddu M, La Regina G, Gianni S, Silvestri R. Nalli M, et al. Among authors: puxeddu m. Molecules. 2021 Dec 9;26(24):7463. doi: 10.3390/molecules26247463. Molecules. 2021. PMID: 34946546 Free PMC article. Review.
35 results