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Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling.
Brewer A, Zhao JF, Fasimoye R, Shpiro N, Macartney TJ, Wood NT, Wightman M, Alessi DR, Sapkota GP. Brewer A, et al. Among authors: sapkota gp. iScience. 2024 Jul 5;27(8):110423. doi: 10.1016/j.isci.2024.110423. eCollection 2024 Aug 16. iScience. 2024. PMID: 39104417 Free PMC article.
Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes.
Morgan CP, Skippen A, Segui B, Ball A, Allen-Baume V, Larijani B, Murray-Rust J, McDonald N, Sapkota G, Morrice N, Cockcroft S. Morgan CP, et al. J Biol Chem. 2004 Nov 5;279(45):47159-71. doi: 10.1074/jbc.M405827200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322105 Free article.
Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).
Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS. Tan L, et al. J Med Chem. 2015 Jan 8;58(1):183-96. doi: 10.1021/jm500480k. Epub 2014 Jul 30. J Med Chem. 2015. PMID: 25075558 Free PMC article.
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Sapkota GP, et al. J Biol Chem. 2001 Jun 1;276(22):19469-82. doi: 10.1074/jbc.M009953200. Epub 2001 Jan 31. J Biol Chem. 2001. PMID: 11297520 Free article.
61 results