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Hif-2α programs oxygen chemosensitivity in chromaffin cells.
Prange-Barczynska M, Jones HA, Sugimoto Y, Cheng X, Lima JD, Ratnayaka I, Douglas G, Buckler KJ, Ratcliffe PJ, Keeley TP, Bishop T. Prange-Barczynska M, et al. Among authors: ratnayaka i. J Clin Invest. 2024 Aug 6;134(18):e174661. doi: 10.1172/JCI174661. J Clin Invest. 2024. PMID: 39106106 Free PMC article.
PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.
Fielding JW, Hodson EJ, Cheng X, Ferguson DJP, Eckardt L, Adam J, Lip P, Maton-Howarth M, Ratnayaka I, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T. Fielding JW, et al. Among authors: ratnayaka i. J Physiol. 2018 Jun 19;596(18):4393-412. doi: 10.1113/JP275996. Online ahead of print. J Physiol. 2018. PMID: 29917232 Free PMC article.
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.
Ma J, Al Moussawi K, Lou H, Chan HF, Wang Y, Chadwick J, Phetsouphanh C, Slee EA, Zhong S, Leissing TM, Roth A, Qin X, Chen S, Yin J, Ratnayaka I, Hu Y, Louphrasitthiphol P, Taylor L, Bettencourt PJG, Muers M, Greaves DR, McShane H, Goldin R, Soilleux EJ, Coleman ML, Ratcliffe PJ, Lu X. Ma J, et al. Among authors: ratnayaka i. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2309957121. doi: 10.1073/pnas.2309957121. Epub 2024 Feb 29. Proc Natl Acad Sci U S A. 2024. PMID: 38422022 Free PMC article.
Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.
Sacilotto N, Monteiro R, Fritzsche M, Becker PW, Sanchez-Del-Campo L, Liu K, Pinheiro P, Ratnayaka I, Davies B, Goding CR, Patient R, Bou-Gharios G, De Val S. Sacilotto N, et al. Among authors: ratnayaka i. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11893-8. doi: 10.1073/pnas.1300805110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818617 Free PMC article.
MEF2 transcription factors are key regulators of sprouting angiogenesis.
Sacilotto N, Chouliaras KM, Nikitenko LL, Lu YW, Fritzsche M, Wallace MD, Nornes S, García-Moreno F, Payne S, Bridges E, Liu K, Biggs D, Ratnayaka I, Herbert SP, Molnár Z, Harris AL, Davies B, Bond GL, Bou-Gharios G, Schwarz JJ, De Val S. Sacilotto N, et al. Among authors: ratnayaka i. Genes Dev. 2016 Oct 15;30(20):2297-2309. doi: 10.1101/gad.290619.116. Genes Dev. 2016. PMID: 27898394 Free PMC article.
SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence.
Wang XD, Lapi E, Sullivan A, Ratnayaka I, Goldin R, Hay R, Lu X. Wang XD, et al. Among authors: ratnayaka i. Cell Death Differ. 2011 Feb;18(2):304-14. doi: 10.1038/cdd.2010.101. Epub 2010 Aug 27. Cell Death Differ. 2011. PMID: 20798689 Free PMC article.
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