Segal RA - Search Results

1

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma.

Tsiami F, Lago C, Pozza N, Piccioni F, Zhao X, Lülsberg F, Root DE, Tiberi L, Kool M, Schittenhelm J, Bandopadhayay P, Segal RA, Tabatabai G, Merk DJ. Tsiami F, et al. Among authors: segal ra. Acta Neuropathol Commun. 2024 Aug 7;12(1):125. doi: 10.1186/s40478-024-01831-x. Acta Neuropathol Commun. 2024. PMID: 39107797 Free PMC article.

2

Sonic Hedgehog Signaling is Blue: Insights from the Patched Mutant Mice.

Merk DJ, Segal RA. Merk DJ, et al. Among authors: segal ra. Trends Neurosci. 2018 Dec;41(12):870-872. doi: 10.1016/j.tins.2018.08.013. Trends Neurosci. 2018. PMID: 30471664 Review.

3

A Polyamine Twist on Hedgehog Signaling.

Zhao X, Segal RA. Zhao X, et al. Among authors: segal ra. Dev Cell. 2015 Oct 12;35(1):1-2. doi: 10.1016/j.devcel.2015.09.024. Dev Cell. 2015. PMID: 26460938 Free article.

4

A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.

Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, Agar NYR, Rubin LL, Qi J, Merk DJ, Segal RA. Pak E, et al. Among authors: segal ra. Neuro Oncol. 2019 Sep 6;21(9):1150-1163. doi: 10.1093/neuonc/noz089. Neuro Oncol. 2019. PMID: 31111916 Free PMC article.

5

The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.

Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA. Merk DJ, et al. Among authors: segal ra. Dev Neurosci. 2020;42(5-6):170-186. doi: 10.1159/000512976. Epub 2021 Jan 20. Dev Neurosci. 2020. PMID: 33472197 Free PMC article.

6

Developmental basis of SHH medulloblastoma heterogeneity.

Gold MP, Ong W, Masteller AM, Ghasemi DR, Galindo JA, Park NR, Huynh NC, Donde A, Pister V, Saurez RA, Vladoiu MC, Hwang GH, Eisemann T, Donovan LK, Walker AD, Benetatos J, Dufour C, Garzia L, Segal RA, Wechsler-Reya RJ, Mesirov JP, Korshunov A, Pajtler KW, Pomeroy SL, Ayrault O, Davidson SM, Cotter JA, Taylor MD, Fraenkel E. Gold MP, et al. Among authors: segal ra. Nat Commun. 2024 Jan 8;15(1):270. doi: 10.1038/s41467-023-44300-0. Nat Commun. 2024. PMID: 38191555 Free PMC article.

7

Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis.

Zhou P, Alfaro J, Chang EH, Zhao X, Porcionatto M, Segal RA. Zhou P, et al. Among authors: segal ra. Dev Cell. 2011 May 17;20(5):610-22. doi: 10.1016/j.devcel.2011.04.006. Dev Cell. 2011. PMID: 21571219 Free PMC article.

8

A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors.

Zhao X, Pak E, Ornell KJ, Pazyra-Murphy MF, MacKenzie EL, Chadwick EJ, Ponomaryov T, Kelleher JF, Segal RA. Zhao X, et al. Among authors: segal ra. Cancer Discov. 2017 Dec;7(12):1436-1449. doi: 10.1158/2159-8290.CD-17-0281. Epub 2017 Sep 18. Cancer Discov. 2017. PMID: 28923910

9

RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA. Zhao X, et al. Among authors: segal ra. Cancer Res. 2015 Sep 1;75(17):3623-35. doi: 10.1158/0008-5472.CAN-14-2999-T. Epub 2015 Jun 30. Cancer Res. 2015. PMID: 26130651 Free PMC article.

10

Tyrosine receptor kinase B is a drug target in astrocytomas.

Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Ni J, et al. Among authors: segal ra. Neuro Oncol. 2017 Jan;19(1):22-30. doi: 10.1093/neuonc/now139. Epub 2016 Jul 10. Neuro Oncol. 2017. PMID: 27402815 Free PMC article.

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