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A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds.
Verheul TCJ, Gillemans N, Putzker K, Majied R, Li T, Vasiliou M, Eussen B, de Klein A, van IJcken WFJ, van den Akker E, von Lindern M, Lewis J, Uhrig U, Nakamura Y, van Dijk T, Philipsen S. Verheul TCJ, et al. Among authors: philipsen s. Hemasphere. 2024 Aug 6;8(8):e139. doi: 10.1002/hem3.139. eCollection 2024 Aug. Hemasphere. 2024. PMID: 39108322 Free PMC article.
Hemoglobin switching in mice carrying the Klf1Nan variant.
Korporaal A, Gillemans N, Heshusius S, Cantú I, van den Akker E, van Dijk TB, von Lindern M, Philipsen S. Korporaal A, et al. Among authors: philipsen s. Haematologica. 2021 Feb 1;106(2):464-473. doi: 10.3324/haematol.2019.239830. Haematologica. 2021. PMID: 32467144 Free PMC article.
Fetal globin expression is regulated by Friend of Prmt1.
van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S. van Dijk TB, et al. Among authors: philipsen s. Blood. 2010 Nov 18;116(20):4349-52. doi: 10.1182/blood-2010-03-274399. Epub 2010 Aug 5. Blood. 2010. PMID: 20688955 Free PMC article.
A ubiquitin ligase toggles red cell differentiation.
Verheul TCJ, Philipsen S. Verheul TCJ, et al. Among authors: philipsen s. Blood. 2021 Jan 14;137(2):143-144. doi: 10.1182/blood.2020009697. Blood. 2021. PMID: 33443559 Free article. No abstract available.
Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency.
Wessels MW, Cnossen MH, van Dijk TB, Gillemans N, Schmidt KLJ, van Lom K, Vinjamur DS, Coyne S, Kurita R, Nakamura Y, de Man SA, Pfundt R, Azmani Z, Brouwer RWW, Bauer DE, van den Hout MCGN, van IJcken WFJ, Philipsen S. Wessels MW, et al. Among authors: philipsen s. Blood Adv. 2021 May 11;5(9):2339-2349. doi: 10.1182/bloodadvances.2020003753. Blood Adv. 2021. PMID: 33938942 Free PMC article.
Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts.
Heshusius S, Grech L, Gillemans N, Brouwer RWW, den Dekker XT, van IJcken WFJ, Nota B, Felice AE, van Dijk TB, von Lindern M, Borg J, van den Akker E, Philipsen S. Heshusius S, et al. Among authors: philipsen s. Sci Rep. 2022 Jan 10;12(1):336. doi: 10.1038/s41598-021-04126-6. Sci Rep. 2022. PMID: 35013432 Free PMC article.
Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.
Pourfarzad F, von Lindern M, Azarkeivan A, Hou J, Kia SK, Esteghamat F, van Ijcken W, Philipsen S, Najmabadi H, Grosveld F. Pourfarzad F, et al. Among authors: philipsen s. Haematologica. 2013 May;98(5):696-704. doi: 10.3324/haematol.2012.074492. Epub 2012 Oct 25. Haematologica. 2013. PMID: 23100274 Free PMC article.
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
Cantú I, van de Werken HJG, Gillemans N, Stadhouders R, Heshusius S, Maas A, Esteghamat F, Ozgur Z, van IJcken WFJ, Grosveld F, von Lindern M, Philipsen S, van Dijk TB. Cantú I, et al. Among authors: philipsen s. PLoS One. 2019 Mar 28;14(3):e0208659. doi: 10.1371/journal.pone.0208659. eCollection 2019. PLoS One. 2019. PMID: 30921348 Free PMC article.
The DNA binding factor Hmg20b is a repressor of erythroid differentiation.
Esteghamat F, van Dijk TB, Braun H, Dekker S, van der Linden R, Hou J, Fanis P, Demmers J, van IJcken W, Ozgür Z, Horos R, Pourfarzad F, von Lindern M, Philipsen S. Esteghamat F, et al. Among authors: philipsen s. Haematologica. 2011 Sep;96(9):1252-60. doi: 10.3324/haematol.2011.045211. Epub 2011 May 23. Haematologica. 2011. PMID: 21606163 Free PMC article.
145 results