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Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel.
Duse DA, Schröder NH, Srivastava T, Benkhoff M, Vogt J, Nowak MK, Funk F, Semleit N, Wollnitzke P, Erkens R, Kötter S, Meuth SG, Keul P, Santos W, Polzin A, Kelm M, Krüger M, Schmitt J, Levkau B. Duse DA, et al. Among authors: levkau b. Basic Res Cardiol. 2024 Oct;119(5):853-868. doi: 10.1007/s00395-024-01073-x. Epub 2024 Aug 7. Basic Res Cardiol. 2024. PMID: 39110173 Free PMC article.
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert AS, Stühler K, Proksch P, Stork B, Wesselborg S. Stuhldreier F, et al. Among authors: levkau b. Cell Death Dis. 2022 Nov 8;13(11):938. doi: 10.1038/s41419-022-05356-w. Cell Death Dis. 2022. PMID: 36347842 Free PMC article.
SYSTEMI - systemic organ communication in STEMI: design and rationale of a cohort study of patients with ST-segment elevation myocardial infarction.
Bönner F, Jung C, Polzin A, Erkens R, Dannenberg L, Ipek R, Kaldirim M, Cramer M, Wischmann P, Zaharia OP, Meyer C, Flögel U, Levkau B, Gödecke A, Fischer J, Klöcker N, Krüger M, Roden M, Kelm M. Bönner F, et al. Among authors: levkau b. BMC Cardiovasc Disord. 2023 May 3;23(1):232. doi: 10.1186/s12872-023-03210-1. BMC Cardiovasc Disord. 2023. PMID: 37138228 Free PMC article.
Sphingosine-1-phosphate promotes osteogenesis by stimulating osteoblast growth and neovascularization in a vascular endothelial growth factor-dependent manner.
Wille A, Weske S, von Wnuck Lipinski K, Wollnitzke P, Schröder NH, Thomas N, Nowak MK, Deister-Jonas J, Behr B, Keul P, Levkau B. Wille A, et al. Among authors: levkau b. J Bone Miner Res. 2024 Apr 19;39(3):357-372. doi: 10.1093/jbmr/zjae006. J Bone Miner Res. 2024. PMID: 38477738 Free PMC article.
Characterization of the dehydrogenase-reductase DHRS2 and its involvement in histone deacetylase inhibition in urological malignancies.
Müller MR, Burmeister A, Skowron MA, Stephan A, Söhngen C, Wollnitzke P, Petzsch P, Alves Avelar LA, Kurz T, Köhrer K, Levkau B, Nettersheim D. Müller MR, et al. Among authors: levkau b. Exp Cell Res. 2024 Jun 1;439(1):114055. doi: 10.1016/j.yexcr.2024.114055. Epub 2024 May 3. Exp Cell Res. 2024. PMID: 38704080 Free article.
Targeting Sphingosine-1-Phosphate Signaling to Prevent the Progression of Aortic Valve Disease.
Benkhoff M, Barcik M, Mourikis P, Dahlmanns J, Kahmann P, Wollnitzke P, Hering M, Huckenbeck T, Hoppe J, Semleit N, Deister-Jonas J, Zako S, Seel J, Coman C, Barth M, Cramer M, Helten C, Wildeis L, Hu H, Al-Kassis G, Metzen D, Hesse J, Weber J, Dannenberg L, Akhyari P, Lichtenberg A, Quast C, Gerdes N, Zeus T, Borst O, Kelm M, Petzold T, Ahrends R, Levkau B, Polzin A. Benkhoff M, et al. Among authors: levkau b. Circulation. 2024 Oct 21. doi: 10.1161/CIRCULATIONAHA.123.067270. Online ahead of print. Circulation. 2024. PMID: 39429140
Pharmacological elevation of sphingosine-1-phosphate by S1P lyase inhibition accelerates bone regeneration after post-traumatic osteomyelitis.
Wagner JM, Wille A, Fueth M, Weske S, Lotzien S, Reinkemeier F, Wallner C, Sogorski A, Dittfeld S, Becerikli M, Schildhauer TA, Lehnhardt M, Levkau B, Behr B. Wagner JM, et al. Among authors: levkau b. J Cell Mol Med. 2023 Dec;27(23):3786-3795. doi: 10.1111/jcmm.17952. Epub 2023 Sep 14. J Cell Mol Med. 2023. PMID: 37710406 Free PMC article.
169 results