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In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.
Nagesh PT, Cho Y, Zhuang Y, Babuta M, Ortega-Ribera M, Joshi R, Brezani V, Patel A, Datta AA, Brezani V, Hsieh YC, Ramos A, Mehta J, Copeland C, Kanata E, Jiang ZG, Vlachos I, Asara J; AlcHepNet Consortium; Szabo G. Nagesh PT, et al. Among authors: cho y. Sci Transl Med. 2024 Aug 7;16(759):eadg1915. doi: 10.1126/scitranslmed.adg1915. Epub 2024 Aug 7. Sci Transl Med. 2024. PMID: 39110779
Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation.
de Carvalho Ribeiro M, Iracheta-Vellve A, Babuta M, Calenda CD, Copeland C, Zhuang Y, Lowe PP, Hawryluk D, Catalano D, Cho Y, Barton B, Dasarathy S, McClain C, McCullough AJ, Mitchell MC, Nagy LE, Radaeva S, Lien E, Golenbock DT, Szabo G. de Carvalho Ribeiro M, et al. Among authors: cho y. Hepatology. 2023 Jul 1;78(1):225-242. doi: 10.1097/HEP.0000000000000298. Epub 2023 Mar 3. Hepatology. 2023. PMID: 36862512
Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis.
Babuta M, Morel C, de Carvalho Ribeiro M, Calenda C, Ortega-Ribera M, Thevkar Nagesh P, Copeland C, Zhuang Y, Wang Y, Cho Y, Joshi R, Brezani V, Hawryluk D, Datta AA, Mehta J, Nasser I, Szabo G. Babuta M, et al. Among authors: cho y. Gut. 2024 Oct 7;73(11):1854-1869. doi: 10.1136/gutjnl-2023-331447. Gut. 2024. PMID: 38777573 Free PMC article.
Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.
Lowe PP, Morel C, Ambade A, Iracheta-Vellve A, Kwiatkowski E, Satishchandran A, Furi I, Cho Y, Gyongyosi B, Catalano D, Lefebvre E, Fischer L, Seyedkazemi S, Schafer DP, Szabo G. Lowe PP, et al. Among authors: cho y. J Neuroinflammation. 2020 Oct 9;17(1):296. doi: 10.1186/s12974-020-01972-5. J Neuroinflammation. 2020. PMID: 33036616 Free PMC article.
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