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Page 1
T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study.
Gainor JF, Patel MR, Weber JS, Gutierrez M, Bauman JE, Clarke JM, Julian R, Scott AJ, Geiger JL, Kirtane K, Robert-Tissot C, Coder B, Tasneem M, Sun J, Zheng W, Gerbereux L, Laino A, Porichis F, Pollard JR, Hou P, Sehgal V, Chen X, Morrissey M, Daghestani HN, Feldman I, Srinivasan L, Frederick JP, Brown M, Aanur P, Meehan R, Burris HA 3rd. Gainor JF, et al. Among authors: porichis f. Cancer Discov. 2024 Nov 1;14(11):2209-2223. doi: 10.1158/2159-8290.CD-24-0158. Cancer Discov. 2024. PMID: 39115419 Clinical Trial.
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ, Kavanagh DG, Kaufmann DE. Porichis F, et al. Blood. 2011 Jul 28;118(4):965-74. doi: 10.1182/blood-2010-12-328070. Epub 2011 Jun 7. Blood. 2011. PMID: 21652684 Free PMC article.
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DE. Ndhlovu ZM, et al. Among authors: porichis f. Blood. 2013 Jan 31;121(5):801-11. doi: 10.1182/blood-2012-06-436295. Epub 2012 Dec 11. Blood. 2013. PMID: 23233659 Free PMC article. Clinical Trial.
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE. Brockman MA, et al. Among authors: porichis f. Blood. 2009 Jul 9;114(2):346-56. doi: 10.1182/blood-2008-12-191296. Epub 2009 Apr 13. Blood. 2009. PMID: 19365081 Free PMC article.
Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.
Gandhi RT, Kwon DS, Macklin EA, Shopis JR, McLean AP, McBrine N, Flynn T, Peter L, Sbrolla A, Kaufmann DE, Porichis F, Walker BD, Bhardwaj N, Barouch DH, Kavanagh DG. Gandhi RT, et al. Among authors: porichis f. J Acquir Immune Defic Syndr. 2016 Mar 1;71(3):246-53. doi: 10.1097/QAI.0000000000000852. J Acquir Immune Defic Syndr. 2016. PMID: 26379068 Free PMC article. Clinical Trial.
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Toure M, Johnson T, Li B, Schmidt R, Ma H, Neagu C, Lopez AU, Wang Y, Guler S, Xiao Y, Henkes R, Ho K, Zhang S, Chu CL, Gundra UM, Porichis F, Li L, Maurer CK, Fang Z, Musil D, DiPoto M, Friis E, Jones R, Jones C, Cummings J, Chekler E, Tanzer EM, Huck B, Sherer B. Toure M, et al. Among authors: porichis f. Bioorg Med Chem. 2023 Sep 7;92:117423. doi: 10.1016/j.bmc.2023.117423. Epub 2023 Jul 27. Bioorg Med Chem. 2023. PMID: 37531921
Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells.
Porichis F, Hart MG, Massa A, Everett HL, Morou A, Richard J, Brassard N, Veillette M, Hassan M, Ly NL, Routy JP, Freeman GJ, Dubé M, Finzi A, Kaufmann DE. Porichis F, et al. J Immunol. 2018 Aug 1;201(3):971-981. doi: 10.4049/jimmunol.1701551. Epub 2018 Jun 22. J Immunol. 2018. PMID: 29934472 Free PMC article.
36 results