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Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.
Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA Jr, Davey RA. Keiser PT, et al. Among authors: saeed m. Antiviral Res. 2024 Oct;230:105976. doi: 10.1016/j.antiviral.2024.105976. Epub 2024 Aug 6. Antiviral Res. 2024. PMID: 39117283
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2.
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Hekman RM, et al. Among authors: saeed m. Mol Cell. 2020 Dec 17;80(6):1104-1122.e9. doi: 10.1016/j.molcel.2020.11.028. Epub 2020 Nov 19. Mol Cell. 2020. PMID: 33259812 Free PMC article.
Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus.
Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Chen DY, et al. Among authors: saeed m. iScience. 2023 May 19;26(5):106634. doi: 10.1016/j.isci.2023.106634. Epub 2023 Apr 10. iScience. 2023. PMID: 37095858 Free PMC article.
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: saeed m. J Virol. 2021 Sep 9;95(19):e0086221. doi: 10.1128/JVI.00862-21. Epub 2021 Sep 9. J Virol. 2021. PMID: 34260266 Free PMC article.
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.
Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Chen DY, et al. Among authors: saeed m. Nature. 2023 Mar;615(7950):143-150. doi: 10.1038/s41586-023-05697-2. Epub 2023 Jan 11. Nature. 2023. PMID: 36630998
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2.
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Hekman RM, et al. Among authors: saeed m. Mol Cell. 2021 Jan 7;81(1):212. doi: 10.1016/j.molcel.2020.12.028. Mol Cell. 2021. PMID: 33417854 Free PMC article. No abstract available.
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection.
Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Kenney DJ, et al. Among authors: saeed m. Cell Rep. 2022 Apr 19;39(3):110714. doi: 10.1016/j.celrep.2022.110714. Epub 2022 Apr 4. Cell Rep. 2022. PMID: 35421379 Free PMC article.
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: saeed m. bioRxiv [Preprint]. 2020 Oct 28:2020.10.27.358259. doi: 10.1101/2020.10.27.358259. bioRxiv. 2020. PMID: 33140044 Free PMC article. Preprint.
The HLA-II immunopeptidome of SARS-CoV-2.
Weingarten-Gabbay S, Chen DY, Sarkizova S, Taylor HB, Gentili M, Hernandez GM, Pearlman LR, Bauer MR, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. Weingarten-Gabbay S, et al. Among authors: saeed m. Cell Rep. 2024 Jan 23;43(1):113596. doi: 10.1016/j.celrep.2023.113596. Epub 2023 Dec 20. Cell Rep. 2024. PMID: 38117652 Free PMC article.
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication.
Loffredo M, Lucero H, Chen DY, O'Connell A, Bergqvist S, Munawar A, Bandara A, De Graef S, Weeks SD, Douam F, Saeed M, Munawar AH. Loffredo M, et al. Among authors: saeed m. Sci Rep. 2021 Mar 8;11(1):5433. doi: 10.1038/s41598-021-84782-w. Sci Rep. 2021. PMID: 33686143 Free PMC article.
2,429 results