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Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers.
Loi P, Schade AE, Rodriguez CL, Krishnan A, Perurena N, Nguyen VTM, Xu Y, Watanabe M, Davis RA, Gardner A, Pilla NF, Mattioli K, Popow O, Gunduz N, Lannagan TRM, Fitzgerald S, Sicinska ET, Lin JR, Tan W, Brais LK, Haigis KM, Giannakis M, Ng K, Santagata S, Helin K, Sansom OJ, Cichowski K. Loi P, et al. Among authors: sansom oj. Cancer Discov. 2024 Dec 2;14(12):2430-2449. doi: 10.1158/2159-8290.CD-23-0866. Cancer Discov. 2024. PMID: 39121480 Free PMC article.
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Port J, Muthalagu N, Raja M, Ceteci F, Monteverde T, Kruspig B, Hedley A, Kalna G, Lilla S, Neilson L, Brucoli M, Gyuraszova K, Tait-Mulder J, Mezna M, Svambaryte S, Bryson A, Sumpton D, McVie A, Nixon C, Drysdale M, Esumi H, Murray GI, Sansom OJ, Zanivan SR, Murphy DJ. Port J, et al. Among authors: sansom oj. Cancer Discov. 2018 May;8(5):632-647. doi: 10.1158/2159-8290.CD-17-0533. Epub 2018 Mar 2. Cancer Discov. 2018. PMID: 29500295 Free PMC article.
Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma.
Muthalagu N, Monteverde T, Raffo-Iraolagoitia X, Wiesheu R, Whyte D, Hedley A, Laing S, Kruspig B, Upstill-Goddard R, Shaw R, Neidler S, Rink C, Karim SA, Gyuraszova K, Nixon C, Clark W, Biankin AV, Carlin LM, Coffelt SB, Sansom OJ, Morton JP, Murphy DJ. Muthalagu N, et al. Among authors: sansom oj. Cancer Discov. 2020 Jun;10(6):872-887. doi: 10.1158/2159-8290.CD-19-0620. Epub 2020 Mar 21. Cancer Discov. 2020. PMID: 32200350 Free PMC article.
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JD, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. Knight JRP, et al. Among authors: sansom oj. Cancer Discov. 2021 May;11(5):1228-1247. doi: 10.1158/2159-8290.CD-20-0652. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328217 Free PMC article.
Advances in colon cancer research: in vitro and animal models.
Lannagan TR, Jackstadt R, Leedham SJ, Sansom OJ. Lannagan TR, et al. Among authors: sansom oj. Curr Opin Genet Dev. 2021 Feb;66:50-56. doi: 10.1016/j.gde.2020.12.003. Epub 2021 Jan 7. Curr Opin Genet Dev. 2021. PMID: 33422950 Free PMC article. Review.
BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer.
Ramesh P, Lannagan TRM, Jackstadt R, Atencia Taboada L, Lansu N, Wirapati P, van Hooff SR, Dekker D, Pritchard J, Kirov AB, van Neerven SM, Tejpar S, Kops GJPL, Sansom OJ, Medema JP. Ramesh P, et al. Among authors: sansom oj. Cell Death Differ. 2021 Dec;28(12):3282-3296. doi: 10.1038/s41418-021-00816-w. Epub 2021 Jun 11. Cell Death Differ. 2021. PMID: 34117376 Free PMC article.
Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.
Freckmann EC, Sandilands E, Cumming E, Neilson M, Román-Fernández A, Nikolatou K, Nacke M, Lannagan TRM, Hedley A, Strachan D, Salji M, Morton JP, McGarry L, Leung HY, Sansom OJ, Miller CJ, Bryant DM. Freckmann EC, et al. Among authors: sansom oj. Nat Commun. 2022 Sep 9;13(1):5317. doi: 10.1038/s41467-022-32958-x. Nat Commun. 2022. PMID: 36085324 Free PMC article.
USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.
Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, Hahn WC, Morton JP, Sansom OJ, Aguirre AJ, Cichowski K. Perurena N, et al. Among authors: sansom oj. Cell Rep Med. 2023 Apr 18;4(4):101007. doi: 10.1016/j.xcrm.2023.101007. Epub 2023 Apr 7. Cell Rep Med. 2023. PMID: 37030295 Free PMC article.
368 results