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Targeting host inducible-heat shock protein 70 with PES-Cl is a promising antiviral strategy against SARS-CoV-2 infection and pathogenesis.
Joshi P, Garg S, Mani S, Shoaib R, Jakhar K, Almuqdadi HTA, Sonar S, Marothia M, Behl A, Biswas S, Singhal J, Kahlon AK, Shevtsov M, Abid M, Garg P, Ranganathan A, Singh S. Joshi P, et al. Among authors: mani s. Int J Biol Macromol. 2024 Nov;279(Pt 1):135069. doi: 10.1016/j.ijbiomac.2024.135069. Epub 2024 Aug 24. Int J Biol Macromol. 2024. PMID: 39187102
Identification of an anti-SARS-CoV-2 receptor-binding domain-directed human monoclonal antibody from a naïve semisynthetic library.
Parray HA, Chiranjivi AK, Asthana S, Yadav N, Shrivastava T, Mani S, Sharma C, Vishwakarma P, Das S, Pindari K, Sinha S, Samal S, Ahmed S, Kumar R. Parray HA, et al. Among authors: mani s. J Biol Chem. 2020 Sep 4;295(36):12814-12821. doi: 10.1074/jbc.AC120.014918. Epub 2020 Jul 29. J Biol Chem. 2020. PMID: 32727845 Free PMC article.
Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model.
Shrivastava T, Singh B, Rizvi ZA, Verma R, Goswami S, Vishwakarma P, Jakhar K, Sonar S, Mani S, Bhattacharyya S, Awasthi A, Surjit M. Shrivastava T, et al. Among authors: mani s. Front Immunol. 2021 May 24;12:641447. doi: 10.3389/fimmu.2021.641447. eCollection 2021. Front Immunol. 2021. PMID: 34108961 Free PMC article.
Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virus.
Murugavelu P, Perween R, Shrivastava T, Singh V, Ahmad Parray H, Singh S, Chiranjivi AK, Thiruvengadam R, Singh S, Yadav N, Jakhar K, Sonar S, Mani S, Bhattacharyya S, Sharma C, Vishwakarma P, Khatri R, Kumar Panchal A, Das S, Ahmed S, Samal S, Kshetrapal P, Bhatnagar S, Luthra K, Kumar R. Murugavelu P, et al. Among authors: mani s. Int Immunopharmacol. 2021 Oct;99:108020. doi: 10.1016/j.intimp.2021.108020. Epub 2021 Jul 29. Int Immunopharmacol. 2021. PMID: 34426117 Free PMC article.
Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2.
Dwivedy A, Mariadasse R, Ahmad M, Chakraborty S, Kar D, Tiwari S, Bhattacharyya S, Sonar S, Mani S, Tailor P, Majumdar T, Jeyakanthan J, Biswal BK. Dwivedy A, et al. Among authors: mani s. PLoS Comput Biol. 2021 Sep 13;17(9):e1009384. doi: 10.1371/journal.pcbi.1009384. eCollection 2021 Sep. PLoS Comput Biol. 2021. PMID: 34516563 Free PMC article.
The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Human immunodeficiency virus (HIV-1) gp41.
Perween R, PraveenKumar M, Shrivastava T, Parray HA, Singh V, Singh S, Chiranjivi A, Jakhar K, Sonar S, Tiwari M, Reema, Panchal AK, Sharma C, Rathore DK, Ahamed S, Samal S, Mani S, Bhattacharyya S, Das S, Luthra K, Kumar R. Perween R, et al. Among authors: mani s. Int Immunopharmacol. 2021 Dec;101(Pt B):108187. doi: 10.1016/j.intimp.2021.108187. Epub 2021 Sep 28. Int Immunopharmacol. 2021. PMID: 34649114 Free PMC article.
High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge.
Ujjainiya R, Tyagi A, Sardana V, Naushin S, Bhatheja N, Kumar K, Barman J, Prakash S, Kutum R, Bhaskar AK, Singh P, Chaudhary K, Loomba M, Khanna Y, Walecha C, Ahmed R, Yadav A, Bajaj A, Malik G, Qureshi S, Waghdhare S, Siddiqui S, Trehan KK, Mani M, Dang R, Das P, Dougall P, Mahajan M, Sonar S, Jakhar K, Kumar R, Tiwari M, Mani S, Bhattacharyya S, Budhiraja S, Agrawal A, Dash D, Jha S, Sengupta S. Ujjainiya R, et al. Among authors: mani m, mani s. Nat Commun. 2022 Apr 1;13(1):1726. doi: 10.1038/s41467-022-29404-3. Nat Commun. 2022. PMID: 35365648 Free PMC article.
Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach.
Khatri R, Parray HA, Agrahari AK, Rizvi ZA, Kaul R, Raj S, Asthana S, Mani S, Samal S, Awasthi A, Ahmed S. Khatri R, et al. Among authors: mani s. Int J Biol Macromol. 2022 Jun 1;209(Pt A):1359-1367. doi: 10.1016/j.ijbiomac.2022.04.148. Epub 2022 Apr 22. Int J Biol Macromol. 2022. PMID: 35469951 Free PMC article.
A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant.
Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, Ansari MY, Burns A, Barman S, Zhao F, Mukherjee S, Torres JL, Chattopadhyay S, Mehdi F, Sutar J, Rathore DK, Pargai K, Singh J, Sonar S, Jakhar K, Dandotiya J, Bhattacharyya S, Mani S, Samal S, Singh S, Kshetrapal P, Thiruvengadam R, Batra G, Medigeshi G, Ward AB, Bhatnagar S, Awasthi A, Sok D, Bhattacharya J. Hingankar N, et al. Among authors: mani s. PLoS Pathog. 2022 Apr 28;18(4):e1010465. doi: 10.1371/journal.ppat.1010465. eCollection 2022 Apr. PLoS Pathog. 2022. PMID: 35482816 Free PMC article.
Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2.
Garg S, Raj N, Lukose A, Jamwal D, Parray HA, Kumar S, Dhyani S, Jakhar K, Sonar S, Tiwari M, Reema, Mani S, Bhattacharyya S, Sharma C, Shrivastava T, Kumar R. Garg S, et al. Among authors: mani s. 3 Biotech. 2022 Sep;12(9):202. doi: 10.1007/s13205-022-03272-6. Epub 2022 Aug 2. 3 Biotech. 2022. PMID: 35928502 Free PMC article.
1,179 results