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A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants.
Liu X, Ng WH, Zusinaite E, Freitas J, Taylor A, Yerragunta V, Aavula SM, Gorriparthi S, Ponsekaran S, Bonda RL, Mani P, Nimmagadda SV, Wang S, Lello LS, Zaid A, Dua U, Taft-Benz SA, Anderson E, Baxter VK, Sarkar S, Ling ZL, Ashhurst TM, Cheng SMS, Pattnaik P, Kanakasapapathy AK, Baric RS, Burt FJ, Peiris M, Heise MT, King NJC, Merits A, Lingala R, Mahalingam S. Liu X, et al. Among authors: king njc. Nat Commun. 2024 Aug 26;15(1):7225. doi: 10.1038/s41467-024-51535-y. Nat Commun. 2024. PMID: 39187479 Free PMC article.
Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation.
Jeong GU, Kwon HJ, Ng WH, Liu X, Moon HW, Yoon GY, Shin HJ, Lee IC, Ling ZL, Spiteri AG, King NJC, Taylor A, Chae JS, Kim C, Ahn DG, Kim KD, Ryu YB, Kim SJ, Mahalingam S, Kwon YC. Jeong GU, et al. Among authors: king njc. Nat Commun. 2022 Dec 12;13(1):7675. doi: 10.1038/s41467-022-35225-1. Nat Commun. 2022. PMID: 36509737 Free PMC article.
FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.
Ng WH, Liu X, Ling ZL, Santos CNO, Magalhães LS, Kueh AJ, Herold MJ, Taylor A, Freitas JR, Koit S, Wang S, Lloyd AR, Teixeira MM, Merits A, Almeida RP, King NJC, Mahalingam S. Ng WH, et al. Among authors: king njc. Nat Commun. 2023 Oct 26;14(1):6605. doi: 10.1038/s41467-023-42330-2. Nat Commun. 2023. PMID: 37884534 Free PMC article.
Basic insights into Zika virus infection of neuroglial and brain endothelial cells.
Mutso M, St John JA, Ling ZL, Burt FJ, Poo YS, Liu X, Žusinaite E, Grau GE, Hueston L, Merits A, King NJC, Ekberg JAK, Mahalingam S. Mutso M, et al. Among authors: king njc. J Gen Virol. 2020 Jun;101(6):622-634. doi: 10.1099/jgv.0.001416. Epub 2020 Apr 28. J Gen Virol. 2020. PMID: 32375993 Free PMC article.
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.
Zhang W, Chua BY, Selva KJ, Kedzierski L, Ashhurst TM, Haycroft ER, Shoffner-Beck SK, Hensen L, Boyd DF, James F, Mouhtouris E, Kwong JC, Chua KYL, Drewett G, Copaescu A, Dobson JE, Rowntree LC, Habel JR, Allen LF, Koay HF, Neil JA, Gartner MJ, Lee CY, Andersson P, Khan SF, Blakeway L, Wisniewski J, McMahon JH, Vine EE, Cunningham AL, Audsley J, Thevarajan I, Seemann T, Sherry NL, Amanat F, Krammer F, Londrigan SL, Wakim LM, King NJC, Godfrey DI, Mackay LK, Thomas PG, Nicholson S, Arnold KB, Chung AW, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Nguyen THO, Kedzierska K. Zhang W, et al. Among authors: king njc. Nat Commun. 2022 May 19;13(1):2774. doi: 10.1038/s41467-022-30088-y. Nat Commun. 2022. PMID: 35589689 Free PMC article.
Zika Virus: Mechanisms of Infection During Pregnancy.
King NJC, Teixeira MM, Mahalingam S. King NJC, et al. Trends Microbiol. 2017 Sep;25(9):701-702. doi: 10.1016/j.tim.2017.05.005. Epub 2017 May 31. Trends Microbiol. 2017. PMID: 28578821
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S. Chen W, et al. Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28. Nat Microbiol. 2017. PMID: 28848230
116 results