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A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants.
Liu X, Ng WH, Zusinaite E, Freitas J, Taylor A, Yerragunta V, Aavula SM, Gorriparthi S, Ponsekaran S, Bonda RL, Mani P, Nimmagadda SV, Wang S, Lello LS, Zaid A, Dua U, Taft-Benz SA, Anderson E, Baxter VK, Sarkar S, Ling ZL, Ashhurst TM, Cheng SMS, Pattnaik P, Kanakasapapathy AK, Baric RS, Burt FJ, Peiris M, Heise MT, King NJC, Merits A, Lingala R, Mahalingam S. Liu X, et al. Among authors: lello ls. Nat Commun. 2024 Aug 26;15(1):7225. doi: 10.1038/s41467-024-51535-y. Nat Commun. 2024. PMID: 39187479 Free PMC article.
4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo.
Yin P, May NA, Lello LS, Fayed A, Parks MG, Drobish AM, Wang S, Andrews M, Sticher Z, Kolykhalov AA, Natchus MG, Painter GR, Merits A, Kielian M, Morrison TE. Yin P, et al. Among authors: lello ls. mBio. 2024 Jun 12;15(6):e0042024. doi: 10.1128/mbio.00420-24. Epub 2024 May 3. mBio. 2024. PMID: 38700353 Free PMC article.
Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agents.
Kangro K, Kurašin M, Gildemann K, Sankovski E, Žusinaite E, Lello LS, Pert R, Kavak A, Poikalainen V, Lepasalu L, Kuusk M, Pau R, Piiskop S, Rom S, Oltjer R, Tiirik K, Kogermann K, Plaas M, Tiirats T, Aasmäe B, Plaas M, Mumm K, Krinka D, Talpsep E, Kadaja M, Gerhold JM, Planken A, Tover A, Merits A, Männik A, Ustav M Jr, Ustav M. Kangro K, et al. Among authors: lello ls. PLoS One. 2022 Jun 10;17(6):e0268806. doi: 10.1371/journal.pone.0268806. eCollection 2022. PLoS One. 2022. PMID: 35687549 Free PMC article.
Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections.
Ianevski A, Yao R, Zusinaite E, Lello LS, Wang S, Jo E, Yang J, Ravlo E, Wang W, Lysvand H, Løseth K, Oksenych V, Tenson T, Windisch MP, Poranen MM, Nieminen AI, Nordbø SA, Fenstad MH, Grødeland G, Aukrust P, Trøseid M, Kantele A, Lastauskienė E, Vitkauskienė A, Legrand N, Merits A, Bjørås M, Kainov DE. Ianevski A, et al. Among authors: lello ls. Viruses. 2021 Dec 11;13(12):2489. doi: 10.3390/v13122489. Viruses. 2021. PMID: 34960758 Free PMC article.
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.
Rihn SJ, Merits A, Bakshi S, Turnbull ML, Wickenhagen A, Alexander AJT, Baillie C, Brennan B, Brown F, Brunker K, Bryden SR, Burness KA, Carmichael S, Cole SJ, Cowton VM, Davies P, Davis C, De Lorenzo G, Donald CL, Dorward M, Dunlop JI, Elliott M, Fares M, da Silva Filipe A, Freitas JR, Furnon W, Gestuveo RJ, Geyer A, Giesel D, Goldfarb DM, Goodman N, Gunson R, Hastie CJ, Herder V, Hughes J, Johnson C, Johnson N, Kohl A, Kerr K, Leech H, Lello LS, Li K, Lieber G, Liu X, Lingala R, Loney C, Mair D, McElwee MJ, McFarlane S, Nichols J, Nomikou K, Orr A, Orton RJ, Palmarini M, Parr YA, Pinto RM, Raggett S, Reid E, Robertson DL, Royle J, Cameron-Ruiz N, Shepherd JG, Smollett K, Stewart DG, Stewart M, Sugrue E, Szemiel AM, Taggart A, Thomson EC, Tong L, Torrie LS, Toth R, Varjak M, Wang S, Wilkinson SG, Wyatt PG, Zusinaite E, Alessi DR, Patel AH, Zaid A, Wilson SJ, Mahalingam S. Rihn SJ, et al. Among authors: lello ls. PLoS Biol. 2021 Feb 25;19(2):e3001091. doi: 10.1371/journal.pbio.3001091. eCollection 2021 Feb. PLoS Biol. 2021. PMID: 33630831 Free PMC article.
Cross-utilisation of template RNAs by alphavirus replicases.
Lello LS, Utt A, Bartholomeeusen K, Wang S, Rausalu K, Kendall C, Coppens S, Fragkoudis R, Tuplin A, Alphey L, Ariën KK, Merits A. Lello LS, et al. PLoS Pathog. 2020 Sep 4;16(9):e1008825. doi: 10.1371/journal.ppat.1008825. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32886709 Free PMC article.
11 results