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Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade.
Holzgruber J, Martins C, Kulcsar Z, Duplaine A, Rasbach E, Migayron L, Singh P, Statham E, Landsberg J, Boniface K, Seneschal J, Hoetzenecker W, Berdan EL, Ho Sui S, Ramsey MR, Barthel SR, Schatton T. Holzgruber J, et al. Among authors: barthel sr. Nat Commun. 2024 Aug 26;15(1):7165. doi: 10.1038/s41467-024-51496-2. Nat Commun. 2024. PMID: 39187481 Free PMC article.
Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis.
Schatton T, Itoh Y, Martins C, Rasbach E, Singh P, Silva M, Mucciarone K, Heppt MV, Geddes-Sweeney J, Stewart K, Brandenburg A, Liang J, Dimitroff CJ, Mihm MC, Landsberg J, Schlapbach C, Lian CG, Murphy GF, Kupper TS, Ramsey MR, Barthel SR. Schatton T, et al. Among authors: barthel sr. Cancer Res. 2022 Oct 17;82(20):3774-3784. doi: 10.1158/0008-5472.CAN-22-0970. Cancer Res. 2022. PMID: 35980306 Free PMC article.
Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling.
Martins C, Rasbach E, Heppt MV, Singh P, Kulcsar Z, Holzgruber J, Chakraborty A, Mucciarone K, Kleffel S, Brandenburg A, Hoetzenecker W, Rahbari NN, DeCaprio JA, Thakuria M, Murphy GF, Ramsey MR, Posch C, Barthel SR, Schatton T. Martins C, et al. Among authors: barthel sr. Sci Adv. 2024 Jan 19;10(3):eadi2012. doi: 10.1126/sciadv.adi2012. Epub 2024 Jan 19. Sci Adv. 2024. PMID: 38241371 Free PMC article.
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.
Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, Mihm MC Jr, Flaherty KT, Frank MH, Murphy GF, Sharpe AH, Kupper TS, Schatton T. Kleffel S, et al. Among authors: barthel sr. Cell. 2015 Sep 10;162(6):1242-56. doi: 10.1016/j.cell.2015.08.052. Cell. 2015. PMID: 26359984 Free PMC article.
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.
Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Cedeno-Laurent F, et al. Among authors: barthel sr. J Invest Dermatol. 2012 Feb;132(2):410-20. doi: 10.1038/jid.2011.335. Epub 2011 Dec 8. J Invest Dermatol. 2012. PMID: 22158550 Free PMC article.
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential.
Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Yazawa EM, et al. Among authors: barthel sr. J Invest Dermatol. 2015 Jul;135(7):1849-1862. doi: 10.1038/jid.2015.95. Epub 2015 Mar 10. J Invest Dermatol. 2015. PMID: 25756799 Free PMC article.
34 results