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Page 1
Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE 3rd, Goodchild TT, Lefer DJ, Elrod JW. Gibb AA, et al. bioRxiv [Preprint]. 2024 Oct 25:2024.10.25.619450. doi: 10.1101/2024.10.25.619450. bioRxiv. 2024. PMID: 39484400 Free PMC article. Preprint.
GPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation.
Joladarashi D, Thej C, Mallaredy V, Magadum A, Cimini M, Gonzalez C, Truongcao M, Nigro JT, Sethi MK, Gibb AA, Benedict C, Koch WJ, Kishore R. Joladarashi D, et al. Among authors: gibb aa. iScience. 2024 Sep 24;27(10):111021. doi: 10.1016/j.isci.2024.111021. eCollection 2024 Oct 18. iScience. 2024. PMID: 39429777 Free PMC article.
Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program.
Lazaropoulos MP, Gibb AA, Chapski DJ, Nair AA, Reiter AN, Roy R, Eaton DM, Bedi KC Jr, Margulies KB, Wellen KE, Estarás C, Vondriska TM, Elrod JW. Lazaropoulos MP, et al. Among authors: gibb aa. Nat Cardiovasc Res. 2024 Jul;3(7):869-882. doi: 10.1038/s44161-024-00502-3. Epub 2024 Jul 5. Nat Cardiovasc Res. 2024. PMID: 39196175 Free PMC article.
Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure.
Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Gibb AA, et al. Circulation. 2022 May 24;145(21):1625-1628. doi: 10.1161/CIRCULATIONAHA.121.057879. Epub 2022 May 23. Circulation. 2022. PMID: 35605036 Free PMC article. No abstract available.
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics.
Gross P, Johnson J, Romero CM, Eaton DM, Poulet C, Sanchez-Alonso J, Lucarelli C, Ross J, Gibb AA, Garbincius JF, Lambert J, Varol E, Yang Y, Wallner M, Feldsott EA, Kubo H, Berretta RM, Yu D, Rizzo V, Elrod J, Sabri A, Gorelik J, Chen X, Houser SR. Gross P, et al. Among authors: gibb aa. Circ Res. 2021 Jan 8;128(1):92-114. doi: 10.1161/CIRCRESAHA.119.315715. Epub 2020 Oct 23. Circ Res. 2021. PMID: 33092464 Free PMC article.
28 results