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A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability.
Ferrara F, Fanni A, Teixeira AAR, Molina E, Leal-Lopes C, DeAguero A, D'Angelo S, Erasmus MF, Spector L, Rodriguez Carnero LA, Li J, Pohl TJ, Suslov N, Desrumeaux K, McMahon C, Kathuria S, Bradbury ARM. Ferrara F, et al. Among authors: mcmahon c. MAbs. 2024 Jan-Dec;16(1):2394230. doi: 10.1080/19420862.2024.2394230. Epub 2024 Aug 27. MAbs. 2024. PMID: 39192463 Free PMC article.
Rapid generation of potent antibodies by autonomous hypermutation in yeast.
Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Wellner A, et al. Among authors: mcmahon c. Nat Chem Biol. 2021 Oct;17(10):1057-1064. doi: 10.1038/s41589-021-00832-4. Epub 2021 Jun 24. Nat Chem Biol. 2021. PMID: 34168368 Free PMC article.
Synthetic nanobodies as angiotensin receptor blockers.
McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. McMahon C, et al. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20284-20291. doi: 10.1073/pnas.2009029117. Epub 2020 Aug 4. Proc Natl Acad Sci U S A. 2020. PMID: 32753386 Free PMC article.
Antibodies expand the scope of angiotensin receptor pharmacology.
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC. Skiba MA, et al. Among authors: mcmahon c. Nat Chem Biol. 2024 May 14:10.1038/s41589-024-01620-6. doi: 10.1038/s41589-024-01620-6. Online ahead of print. Nat Chem Biol. 2024. PMID: 38744986
Antibodies Expand the Scope of Angiotensin Receptor Pharmacology.
Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC. Skiba MA, et al. Among authors: mcmahon c. bioRxiv [Preprint]. 2023 Aug 24:2023.08.23.554128. doi: 10.1101/2023.08.23.554128. bioRxiv. 2023. Update in: Nat Chem Biol. 2024 May 14. doi: 10.1038/s41589-024-01620-6. PMID: 37662341 Free PMC article. Updated. Preprint.
1,235 results