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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Among authors: houdusse a. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.
Structural aspects of Rab6-effector complexes.
Fernandes H, Franklin E, Recacha R, Houdusse A, Goud B, Khan AR. Fernandes H, et al. Among authors: houdusse a. Biochem Soc Trans. 2009 Oct;37(Pt 5):1037-41. doi: 10.1042/BST0371037. Biochem Soc Trans. 2009. PMID: 19754447 Review.
2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology.
Lucchino M, Billet A, Versini A, Bavireddi H, Dasari BD, Debieu S, Colombeau L, Cañeque T, Wagner A, Masson G, Taran F, Karoyan P, Delepierre M, Gaillet C, Houdusse A, Britton S, Schmidt F, Florent JC, Belmont P, Monchaud D, Cossy J, Thomas C, Gautier A, Johannes L, Rodriguez R. Lucchino M, et al. Among authors: houdusse a. Chembiochem. 2019 Apr 1;20(7):968-973. doi: 10.1002/cbic.201900092. Epub 2019 Feb 25. Chembiochem. 2019. PMID: 30803119
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Sirigu S, Hartman JJ, Planelles-Herrero VJ, Ropars V, Clancy S, Wang X, Chuang G, Qian X, Lu PP, Barrett E, Rudolph K, Royer C, Morgan BP, Stura EA, Malik FI, Houdusse AM. Sirigu S, et al. Among authors: houdusse am. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7448-E7455. doi: 10.1073/pnas.1609342113. Epub 2016 Nov 4. Proc Natl Acad Sci U S A. 2016. PMID: 27815532 Free PMC article.
Myosin 7 and its adaptors link cadherins to actin.
Yu IM, Planelles-Herrero VJ, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Yu IM, et al. Among authors: houdusse a. Nat Commun. 2017 Jun 29;8:15864. doi: 10.1038/ncomms15864. Nat Commun. 2017. PMID: 28660889 Free PMC article.
Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism.
Robert-Paganin J, Robblee JP, Auguin D, Blake TCA, Bookwalter CS, Krementsova EB, Moussaoui D, Previs MJ, Jousset G, Baum J, Trybus KM, Houdusse A. Robert-Paganin J, et al. Among authors: houdusse a. Nat Commun. 2019 Jul 23;10(1):3286. doi: 10.1038/s41467-019-11120-0. Nat Commun. 2019. PMID: 31337750 Free PMC article.
110 results