Hwee DT - Search Results

1

Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.

Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Among authors: hwee dt. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.

2

Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.

Hwee DT, Kennedy A, Ryans J, Russell AJ, Jia Z, Hinken AC, Morgans DJ, Malik FI, Jasper JR. Hwee DT, et al. PLoS One. 2014 May 7;9(5):e96921. doi: 10.1371/journal.pone.0096921. eCollection 2014. PLoS One. 2014. PMID: 24805850 Free PMC article.

3

The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure.

Hwee DT, Kennedy AR, Hartman JJ, Ryans J, Durham N, Malik FI, Jasper JR. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68. doi: 10.1124/jpet.114.222224. Epub 2015 Feb 12. J Pharmacol Exp Ther. 2015. PMID: 25678535

4

The Ca²⁺ sensitizer CK-2066260 increases myofibrillar Ca²⁺ sensitivity and submaximal force selectively in fast skeletal muscle.

Hwee DT, Cheng AJ, Hartman JJ, Hinken AC, Lee K, Durham N, Russell AJ, Malik FI, Westerblad H, Jasper JR. Hwee DT, et al. J Physiol. 2017 Mar 1;595(5):1657-1670. doi: 10.1113/JP273248. Epub 2017 Jan 24. J Physiol. 2017. PMID: 27869319 Free PMC article.

5

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

Collibee SE, Bergnes G, Muci A, Browne WF 4th, Garard M, Hinken AC, Russell AJ, Suehiro I, Hartman J, Kawas R, Lu PP, Lee KH, Marquez D, Tomlinson M, Xu D, Kennedy A, Hwee D, Schaletzky J, Leung K, Malik FI, Morgans DJ Jr, Morgan BP. Collibee SE, et al. ACS Med Chem Lett. 2018 Feb 13;9(4):354-358. doi: 10.1021/acsmedchemlett.7b00546. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670700 Free PMC article.

6

Fast skeletal muscle troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction.

Cheng AJ, Hwee DT, Kim LH, Durham N, Yang HT, Hinken AC, Kennedy AR, Terjung RL, Jasper JR, Malik FI, Westerblad H. Cheng AJ, et al. Among authors: hwee dt. J Physiol. 2019 Sep;597(17):4615-4625. doi: 10.1113/JP278235. Epub 2019 Jul 17. J Physiol. 2019. PMID: 31246276 Free PMC article.

7

Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator tirasemtiv.

Lee EJ, Kolb J, Hwee DT, Malik FI, Granzier HL. Lee EJ, et al. Among authors: hwee dt. Int J Mol Sci. 2019 Oct 10;20(20):5008. doi: 10.3390/ijms20205008. Int J Mol Sci. 2019. PMID: 31658633 Free PMC article.

8

Fast skeletal muscle troponin activator CK-2066260 mitigates skeletal muscle weakness independently of the underlying cause.

Cheng AJ, Ström J, Hwee DT, Malik FI, Westerblad H. Cheng AJ, et al. Among authors: hwee dt. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1747-1757. doi: 10.1002/jcsm.12624. Epub 2020 Sep 21. J Cachexia Sarcopenia Muscle. 2020. PMID: 32954682 Free PMC article.

9

Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium.

van de Locht M, Donkervoort S, de Winter JM, Conijn S, Begthel L, Kusters B, Mohassel P, Hu Y, Medne L, Quinn C, Moore SA, Foley AR, Seo G, Hwee DT, Malik FI, Irving T, Ma W, Granzier HL, Kamsteeg EJ, Immadisetty K, Kekenes-Huskey P, Pinto JR, Voermans N, Bönnemann CG, Ottenheijm CA. van de Locht M, et al. Among authors: hwee dt. J Clin Invest. 2021 May 3;131(9):e145700. doi: 10.1172/JCI145700. J Clin Invest. 2021. PMID: 33755597 Free PMC article.

10

Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.

de Winter JM, Gineste C, Minardi E, Brocca L, Rossi M, Borsboom T, Beggs AH, Bernard M, Bendahan D, Hwee DT, Malik FI, Pellegrino MA, Bottinelli R, Gondin J, Ottenheijm CAC. de Winter JM, et al. Among authors: hwee dt. Hum Mol Genet. 2021 Jun 26;30(14):1305-1320. doi: 10.1093/hmg/ddab112. Hum Mol Genet. 2021. PMID: 33909041 Free PMC article.

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