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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Among authors: pernier j. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.
Control of polarized assembly of actin filaments in cell motility.
Carlier MF, Pernier J, Montaville P, Shekhar S, Kühn S; Cytoskeleton Dynamics and Motility group. Carlier MF, et al. Among authors: pernier j. Cell Mol Life Sci. 2015 Aug;72(16):3051-67. doi: 10.1007/s00018-015-1914-2. Epub 2015 May 7. Cell Mol Life Sci. 2015. PMID: 25948416 Free PMC article. Review.
Talin and vinculin combine their activities to trigger actin assembly.
Wang H, Said R, Nguyen-Vigouroux C, Henriot V, Gebhardt P, Pernier J, Grosse R, Le Clainche C. Wang H, et al. Among authors: pernier j. Nat Commun. 2024 Nov 3;15(1):9497. doi: 10.1038/s41467-024-53859-1. Nat Commun. 2024. PMID: 39489770 Free PMC article.
107 results