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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Among authors: robert paganin j. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.
Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Auguin D, Robert-Paganin J, Réty S, Kikuti C, David A, Theumer G, Schmidt AW, Knölker HJ, Houdusse A. Auguin D, et al. Among authors: robert paganin j. bioRxiv [Preprint]. 2023 Nov 15:2023.11.15.567213. doi: 10.1101/2023.11.15.567213. bioRxiv. 2023. Update in: Nat Commun. 2024 Jun 7;15(1):4885. doi: 10.1038/s41467-024-47587-9 PMID: 38014327 Free PMC article. Updated. Preprint.
Cryo-EM structure of the folded-back state of human β-cardiac myosin.
Grinzato A, Auguin D, Kikuti C, Nandwani N, Moussaoui D, Pathak D, Kandiah E, Ruppel KM, Spudich JA, Houdusse A, Robert-Paganin J. Grinzato A, et al. Among authors: robert paganin j. Nat Commun. 2023 May 31;14(1):3166. doi: 10.1038/s41467-023-38698-w. Nat Commun. 2023. PMID: 37258552 Free PMC article.
Cryo-EM structure of the folded-back state of human β-cardiac myosin.
Grinzato A, Auguin D, Kikuti C, Nandwani N, Moussaoui D, Pathak D, Kandiah E, Ruppel KM, Spudich JA, Houdusse A, Robert-Paganin J. Grinzato A, et al. Among authors: robert paganin j. bioRxiv [Preprint]. 2023 Apr 18:2023.04.15.536999. doi: 10.1101/2023.04.15.536999. bioRxiv. 2023. Update in: Nat Commun. 2023 May 31;14(1):3166. doi: 10.1038/s41467-023-38698-w PMID: 37131793 Free PMC article. Updated. Preprint.
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