Sarkar SS - Search Results

1

Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.

Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Among authors: sarkar ss. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.

2

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.

Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM. Adhikari AS, et al. Among authors: sarkar ss. Nat Commun. 2019 Jun 18;10(1):2685. doi: 10.1038/s41467-019-10555-9. Nat Commun. 2019. PMID: 31213605 Free PMC article.

3

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.

Nag S, Trivedi DV, Sarkar SS, Adhikari AS, Sunitha MS, Sutton S, Ruppel KM, Spudich JA. Nag S, et al. Among authors: sarkar ss. Nat Struct Mol Biol. 2017 Jun;24(6):525-533. doi: 10.1038/nsmb.3408. Epub 2017 May 8. Nat Struct Mol Biol. 2017. PMID: 28481356 Free PMC article.

4

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.

Adhikari AS, Kooiker KB, Sarkar SS, Liu C, Bernstein D, Spudich JA, Ruppel KM. Adhikari AS, et al. Among authors: sarkar ss. Cell Rep. 2016 Dec 13;17(11):2857-2864. doi: 10.1016/j.celrep.2016.11.040. Cell Rep. 2016. PMID: 27974200 Free PMC article.

5

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.

Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C, Adhikari AS, Taylor R, Liu C, Trivedi D, Ruppel KM. Spudich JA, et al. Among authors: sarkar ss. J Exp Biol. 2016 Jan;219(Pt 2):161-7. doi: 10.1242/jeb.125930. J Exp Biol. 2016. PMID: 26792326 Free PMC article. Review.

6

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.

Sarkar SS, Trivedi DV, Morck MM, Adhikari AS, Pasha SN, Ruppel KM, Spudich JA. Sarkar SS, et al. Sci Adv. 2020 Apr 3;6(14):eaax0069. doi: 10.1126/sciadv.aax0069. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32284968 Free PMC article.

7

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.

Kawana M, Sarkar SS, Sutton S, Ruppel KM, Spudich JA. Kawana M, et al. Among authors: sarkar ss. Sci Adv. 2017 Feb 10;3(2):e1601959. doi: 10.1126/sciadv.1601959. eCollection 2017 Feb. Sci Adv. 2017. PMID: 28246639 Free PMC article.

8

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.

Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, Spudich JA. Anderson RL, et al. Among authors: sarkar ss. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8143-E8152. doi: 10.1073/pnas.1809540115. Epub 2018 Aug 13. Proc Natl Acad Sci U S A. 2018. PMID: 30104387 Free PMC article.

9

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.

Trivedi DV, Adhikari AS, Sarkar SS, Ruppel KM, Spudich JA. Trivedi DV, et al. Among authors: sarkar ss. Biophys Rev. 2018 Feb;10(1):27-48. doi: 10.1007/s12551-017-0274-6. Epub 2017 Jul 17. Biophys Rev. 2018. PMID: 28717924 Free PMC article. Review.

10

LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma.

Sarkar SS, Sharma M, Saproo S, Naidu S. Sarkar SS, et al. J Transl Med. 2024 Oct 5;22(1):904. doi: 10.1186/s12967-024-05715-5. J Transl Med. 2024. PMID: 39369230 Free PMC article.

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