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Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Farrar GJ. Chadderton N, et al. Among authors: kenna pf. Eur J Hum Genet. 2013 Jan;21(1):62-8. doi: 10.1038/ejhg.2012.112. Epub 2012 Jun 6. Eur J Hum Genet. 2013. PMID: 22669418 Free PMC article.
Novel 199 base pair NEFH promoter drives expression in retinal ganglion cells.
Millington-Ward S, Chadderton N, Berkeley M, Finnegan LK, Hanlon KS, Carrigan M, Humphries P, Kenna PF, Palfi A, Farrar GJ. Millington-Ward S, et al. Among authors: kenna pf. Sci Rep. 2020 Oct 5;10(1):16515. doi: 10.1038/s41598-020-73257-z. Sci Rep. 2020. PMID: 33020509 Free PMC article.
AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models.
Millington-Ward S, Chadderton N, Finnegan LK, Post IJM, Carrigan M, Gardiner T, Peixoto E, Maloney D, Humphries MM, Stitt A, Léveillard T, Humphries P, Kenna PF, Palfi A, Farrar GJ. Millington-Ward S, et al. Among authors: kenna pf. Clin Transl Med. 2022 Aug;12(8):e952. doi: 10.1002/ctm2.952. Clin Transl Med. 2022. PMID: 35988157 Free PMC article. No abstract available.
RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models.
Millington-Ward S, Chadderton N, Finnegan LK, Post IJM, Carrigan M, Nixon R, Humphries MM, Humphries P, Kenna PF, Palfi A, Farrar GJ. Millington-Ward S, et al. Among authors: kenna pf. Int J Mol Sci. 2023 Feb 14;24(4):3847. doi: 10.3390/ijms24043847. Int J Mol Sci. 2023. PMID: 36835257 Free PMC article.
RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: kenna pf. Am J Hum Genet. 2007 Jul;81(1):127-35. doi: 10.1086/519025. Epub 2007 May 23. Am J Hum Genet. 2007. PMID: 17564969 Free PMC article.
A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: kenna pf. Vision Res. 2008 Feb;48(3):386-91. doi: 10.1016/j.visres.2007.08.014. Epub 2007 Oct 24. Vision Res. 2008. PMID: 17920651 Free article.
121 results