O Brien C - Search Results

1

AAV-NDI1 Therapy Provides Significant Benefit to Murine and Cellular Models of Glaucoma.

Millington-Ward S, Palfi A, Shortall C, Finnegan LK, Bargroff E, Post IJM, Maguire J, Irnaten M, O Brien C, Kenna PF, Chadderton N, Farrar GJ. Millington-Ward S, et al. Among authors: o brien c. Int J Mol Sci. 2024 Aug 15;25(16):8876. doi: 10.3390/ijms25168876. Int J Mol Sci. 2024. PMID: 39201561 Free PMC article.

2

Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells.

Irnaten M, Barry RC, Quill B, Clark AF, Harvey BJ, O'Brien CJ. Irnaten M, et al. Among authors: o brien cj. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):194-202. doi: 10.1167/iovs.08-1937. Epub 2008 Sep 4. Invest Ophthalmol Vis Sci. 2009. PMID: 18775862

3

Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.

McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O'Brien CJ, Wallace DM. McElnea EM, et al. Among authors: o brien cj. Mol Vis. 2011;17:1182-91. Epub 2011 May 5. Mol Vis. 2011. PMID: 21617752 Free PMC article.

4

Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells.

Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O'Brien CJ. Irnaten M, et al. Among authors: o brien cj. Exp Eye Res. 2013 Oct;115:224-9. doi: 10.1016/j.exer.2013.07.022. Epub 2013 Jul 29. Exp Eye Res. 2013. PMID: 23906962

5

Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells.

McElnea EM, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M, Farrell M, Clark AF, O'Brien CJ, Wallace DM. McElnea EM, et al. BMC Ophthalmol. 2014 Dec 2;14:153. doi: 10.1186/1471-2415-14-153. BMC Ophthalmol. 2014. PMID: 25444463 Free PMC article.

6

Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells.

Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, Clark AF, O'Brien CJ. Quill B, et al. Among authors: o brien cj. Br J Ophthalmol. 2015 Jul;99(7):1009-14. doi: 10.1136/bjophthalmol-2014-306093. Epub 2015 Mar 20. Br J Ophthalmol. 2015. PMID: 25795916

7

Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells.

McDonnell F, Irnaten M, Clark AF, O'Brien CJ, Wallace DM. McDonnell F, et al. PLoS One. 2016 Apr 28;11(4):e0153354. doi: 10.1371/journal.pone.0153354. eCollection 2016. PLoS One. 2016. PMID: 27124111 Free PMC article.

8

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.

O'Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Stamer WD, Overby DR, O'Brien C, Tam LCS, Humphries P. O'Callaghan J, et al. Among authors: o brien c. Hum Mol Genet. 2017 Apr 1;26(7):1230-1246. doi: 10.1093/hmg/ddx028. Hum Mol Genet. 2017. PMID: 28158775 Free PMC article.

9

Mitochondrial dysfunction in ocular disease: Focus on glaucoma.

Kamel K, Farrell M, O'Brien C. Kamel K, et al. Among authors: o brien c. Mitochondrion. 2017 Jul;35:44-53. doi: 10.1016/j.mito.2017.05.004. Epub 2017 May 9. Mitochondrion. 2017. PMID: 28499981 Review.

10

Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma.

Irnaten M, Zhdanov A, Brennan D, Crotty T, Clark A, Papkovsky D, O'Brien C. Irnaten M, et al. Among authors: o brien c. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):831-842. doi: 10.1167/iovs.17-22531. Invest Ophthalmol Vis Sci. 2018. PMID: 29411011

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