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Page 1
Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.
Vidal-Calvo EE, Martin-Salazar A, Choudhary S, Dagil R, Raghavan SSR, Duvnjak L, Nordmaj MA, Clausen TM, Skafte A, Oberkofler J, Wang K, Agerbæk MØ, Løppke C, Jørgensen AM, Ropac D, Mujollari J, Willis S, Garcias López A, Miller RL, Karlsson RTG, Goerdeler F, Chen YH, Colaço AR, Wang Y, Lavstsen T, Martowicz A, Nelepcu I, Marzban M, Oo HZ, Ørum-Madsen MS, Wang Y, Nielsen MA, Clausen H, Wierer M, Wolf D, Gögenur I, Theander TG, Al-Nakouzi N, Gustavsson T, Daugaard M, Salanti A. Vidal-Calvo EE, et al. Among authors: agerbaek mo. Nat Commun. 2024 Aug 30;15(1):7553. doi: 10.1038/s41467-024-51781-0. Nat Commun. 2024. PMID: 39215044 Free PMC article.
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen TM, Christoffersen S, Dahlbäck M, Langkilde AE, Jensen KE, Resende M, Agerbæk MØ, Andersen D, Berisha B, Ditlev SB, Pinto VV, Nielsen MA, Theander TG, Larsen S, Salanti A. Clausen TM, et al. Among authors: agerbaek mo. J Biol Chem. 2012 Jul 6;287(28):23332-45. doi: 10.1074/jbc.M112.348839. Epub 2012 May 8. J Biol Chem. 2012. PMID: 22570492 Free PMC article.
The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine.
Nielsen MA, Resende M, de Jongh WA, Ditlev SB, Mordmüller B, Houard S, Ndam NT, Agerbæk MØ, Hamborg M, Massougbodji A, Issifou S, Strøbæk A, Poulsen L, Leroy O, Kremsner PG, Chippaux JP, Luty AJ, Deloron P, Theander TG, Dyring C, Salanti A. Nielsen MA, et al. Among authors: agerbaek mo. PLoS One. 2015 Sep 1;10(9):e0135406. doi: 10.1371/journal.pone.0135406. eCollection 2015. PLoS One. 2015. PMID: 26327283 Free PMC article.
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.
Salanti A, Clausen TM, Agerbæk MØ, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M. Salanti A, et al. Among authors: agerbaek mo. Cancer Cell. 2015 Oct 12;28(4):500-514. doi: 10.1016/j.ccell.2015.09.003. Cancer Cell. 2015. PMID: 26461094 Free PMC article.
Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility.
Clausen TM, Pereira MA, Al Nakouzi N, Oo HZ, Agerbæk MØ, Lee S, Ørum-Madsen MS, Kristensen AR, El-Naggar A, Grandgenett PM, Grem JL, Hollingsworth MA, Holst PJ, Theander T, Sorensen PH, Daugaard M, Salanti A. Clausen TM, et al. Among authors: agerbaek mo. Mol Cancer Res. 2016 Dec;14(12):1288-1299. doi: 10.1158/1541-7786.MCR-16-0103. Epub 2016 Sep 21. Mol Cancer Res. 2016. PMID: 27655130 Free PMC article.
Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration.
Agerbaek MØ, Pereira MA, Clausen TM, Pehrson C, Oo HZ, Spliid C, Rich JR, Fung V, Nkrumah F, Neequaye J, Biggar RJ, Reynolds SJ, Tosato G, Pullarkat ST, Ayers LW, Theander TG, Daugaard M, Bhatia K, Nielsen MA, Mbulaiteye SM, Salanti A. Agerbaek MØ, et al. Int J Cancer. 2017 Apr 1;140(7):1597-1608. doi: 10.1002/ijc.30575. Epub 2017 Feb 6. Int J Cancer. 2017. PMID: 27997697 Free PMC article.
An Oncofetal Glycosaminoglycan Modification Provides Therapeutic Access to Cisplatin-resistant Bladder Cancer.
Seiler R, Oo HZ, Tortora D, Clausen TM, Wang CK, Kumar G, Pereira MA, Ørum-Madsen MS, Agerbæk MØ, Gustavsson T, Nordmaj MA, Rich JR, Lallous N, Fazli L, Lee SS, Douglas J, Todenhöfer T, Esfandnia S, Battsogt D, Babcook JS, Al-Nakouzi N, Crabb SJ, Moskalev I, Kiss B, Davicioni E, Thalmann GN, Rennie PS, Black PC, Salanti A, Daugaard M. Seiler R, et al. Among authors: agerbaek mo. Eur Urol. 2017 Jul;72(1):142-150. doi: 10.1016/j.eururo.2017.03.021. Epub 2017 Apr 10. Eur Urol. 2017. PMID: 28408175
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner.
Agerbæk MØ, Bang-Christensen SR, Yang MH, Clausen TM, Pereira MA, Sharma S, Ditlev SB, Nielsen MA, Choudhary S, Gustavsson T, Sorensen PH, Meyer T, Propper D, Shamash J, Theander TG, Aicher A, Daugaard M, Heeschen C, Salanti A. Agerbæk MØ, et al. Nat Commun. 2018 Aug 16;9(1):3279. doi: 10.1038/s41467-018-05793-2. Nat Commun. 2018. PMID: 30115931 Free PMC article.
23 results