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Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead.
Grattoni A, Korbutt G, Tomei AA, García AJ, Pepper AR, Stabler C, Brehm M, Papas K, Citro A, Shirwan H, Millman JR, Melero-Martin J, Graham M, Sefton M, Ma M, Kenyon N, Veiseh O, Desai TA, Nostro MC, Marinac M, Sykes M, Russ HA, Odorico J, Tang Q, Ricordi C, Latres E, Mamrak NE, Giraldo J, Poznansky MC, de Vos P. Grattoni A, et al. Nat Rev Endocrinol. 2025 Jan;21(1):14-30. doi: 10.1038/s41574-024-01029-0. Epub 2024 Sep 3. Nat Rev Endocrinol. 2025. PMID: 39227741 Review.
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats.
Paez-Mayorga J, Campa-Carranza JN, Capuani S, Hernandez N, Liu HC, Chua CYX, Pons-Faudoa FP, Malgir G, Alvarez B, Niles JA, Argueta LB, Shelton KA, Kezar S, Nehete PN, Berman DM, Willman MA, Li XC, Ricordi C, Nichols JE, Gaber AO, Kenyon NS, Grattoni A. Paez-Mayorga J, et al. Among authors: grattoni a. Nat Commun. 2022 Dec 26;13(1):7951. doi: 10.1038/s41467-022-35629-z. Nat Commun. 2022. PMID: 36572684 Free PMC article.
Emerging strategies for beta cell transplantation to treat diabetes.
Paez-Mayorga J, Lukin I, Emerich D, de Vos P, Orive G, Grattoni A. Paez-Mayorga J, et al. Among authors: grattoni a. Trends Pharmacol Sci. 2022 Mar;43(3):221-233. doi: 10.1016/j.tips.2021.11.007. Epub 2021 Dec 6. Trends Pharmacol Sci. 2022. PMID: 34887129 Review.
Emerging immunomodulatory strategies for cell therapeutics.
Chua CYX, Jiang AY, Eufrásio-da-Silva T, Dolatshahi-Pirouz A, Langer R, Orive G, Grattoni A. Chua CYX, et al. Among authors: grattoni a. Trends Biotechnol. 2023 Mar;41(3):358-373. doi: 10.1016/j.tibtech.2022.11.008. Epub 2022 Dec 20. Trends Biotechnol. 2023. PMID: 36549959 Free article. Review.
Technologies for intrapericardial delivery of therapeutics and cells.
Filgueira CS, Igo SR, Wang DK, Hirsch M, Schulz DG, Bruckner BA, Grattoni A. Filgueira CS, et al. Among authors: grattoni a. Adv Drug Deliv Rev. 2019 Nov-Dec;151-152:222-232. doi: 10.1016/j.addr.2019.02.006. Epub 2019 Feb 21. Adv Drug Deliv Rev. 2019. PMID: 30797957 Review.
93 results