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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1.
Venkatraman R, Balka KR, Wong W, Sivamani J, Magill Z, Tullett KM, Lane RM, Saunders TL, Tailler M, Crack PJ, Wakim LM, Lahoud MH, Lawlor KE, Kile BT, O'Keeffe M, De Nardo D. Venkatraman R, et al. Among authors: saunders tl. iScience. 2024 Aug 7;27(9):110693. doi: 10.1016/j.isci.2024.110693. eCollection 2024 Sep 20. iScience. 2024. PMID: 39262777 Free PMC article.
Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.
Yuan T, Kumar S, Skinner ME, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: saunders tl. iScience. 2024 May 15;27(6):109991. doi: 10.1016/j.isci.2024.109991. eCollection 2024 Jun 21. iScience. 2024. PMID: 38846003 Free PMC article.
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy.
Saunders TL, Windley SP, Gervinskas G, Balka KR, Rowe C, Lane R, Tailler M, Nguyen TN, Ramm G, Lazarou M, De Nardo D, Kile BT, McArthur K. Saunders TL, et al. Cell Death Differ. 2024 Mar;31(3):335-347. doi: 10.1038/s41418-024-01260-2. Epub 2024 Feb 23. Cell Death Differ. 2024. PMID: 38396150 Free PMC article.
SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology.
Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: saunders tl. bioRxiv [Preprint]. 2023 Dec 8:2023.12.06.570371. doi: 10.1101/2023.12.06.570371. bioRxiv. 2023. PMID: 38105987 Free PMC article. Preprint.
151 results