Guo L - Search Results

1

Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth.

Guo L, Hong T, Lee YT, Hu X, Pan G, Zhao R, Yang Y, Yang J, Cai X, Rivera L, Liang J, Wang R, Dou Y, Kodali S, Li W, Han L, Di Stefano B, Zhou Y, Li J, Huang Y. Guo L, et al. Nat Cell Biol. 2024 Dec;26(12):2154-2167. doi: 10.1038/s41556-024-01496-7. Epub 2024 Sep 9. Nat Cell Biol. 2024. PMID: 39251719

2

Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development.

Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, Li T, Hill MC, Hong T, Mo W, Xu R, Zhang P, Wang F, Chang J, Zhou Y, Sun D, Martin JF, Huang Y. Fang S, et al. Among authors: guo l. Nat Commun. 2019 Sep 20;10(1):4297. doi: 10.1038/s41467-019-12325-z. Nat Commun. 2019. PMID: 31541101 Free PMC article.

3

Targeting epigenetic regulatory machinery to overcome cancer therapy resistance.

Guo L, Lee YT, Zhou Y, Huang Y. Guo L, et al. Semin Cancer Biol. 2022 Aug;83:487-502. doi: 10.1016/j.semcancer.2020.12.022. Epub 2021 Jan 6. Semin Cancer Biol. 2022. PMID: 33421619 Free PMC article. Review.

4

TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.

Hong T, Li J, Guo L, Cavalier M, Wang T, Dou Y, DeLaFuente A, Fang S, Guzman A, Wohlan K, Kapadia C, Rosas C, Yang Y, Yin CC, Li S, You MJ, Cheng X, Goodell MA, Zhou Y, Huang Y. Hong T, et al. Among authors: guo l. Nat Aging. 2023 Nov;3(11):1387-1400. doi: 10.1038/s43587-023-00505-y. Epub 2023 Oct 26. Nat Aging. 2023. PMID: 37884767 Free PMC article.

5

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.

Guo L, Li J, Zeng H, Guzman AG, Li T, Lee M, Zhou Y, Goodell MA, Stephan C, Davies PJA, Dawson MA, Sun D, Huang Y. Guo L, et al. Nat Commun. 2020 Feb 6;11(1):740. doi: 10.1038/s41467-020-14604-6. Nat Commun. 2020. PMID: 32029739 Free PMC article.

6

Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.

He L, Tan P, Zhu L, Huang K, Nguyen NT, Wang R, Guo L, Li L, Yang Y, Huang Z, Huang Y, Han G, Wang J, Zhou Y. He L, et al. Among authors: guo l. Nat Chem Biol. 2021 Aug;17(8):915-923. doi: 10.1038/s41589-021-00792-9. Epub 2021 May 6. Nat Chem Biol. 2021. PMID: 33958793

7

Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells.

Fang S, Cui D, Hong T, Guo L, Lee YT, Lee M, Isgandarova S, Martinez-Moczygemba M, Zhou Y, Li J, Huang Y. Fang S, et al. Among authors: guo l. Stem Cells. 2022 Mar 31;40(3):260-272. doi: 10.1093/stmcls/sxab017. Stem Cells. 2022. PMID: 35296897

8

Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms.

Li J, Hong T, Wei Y, Guo L, Lee M, Yang H, Class C, Yang Y, Wang X, He H, Siwko S, You MJ, Zhou Y, Garcia-Manero G, Huang Y. Li J, et al. Among authors: guo l. Clin Epigenetics. 2022 Jun 28;14(1):81. doi: 10.1186/s13148-022-01297-5. Clin Epigenetics. 2022. PMID: 35765052 Free PMC article.

9

Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC.

Li J, Wu X, Zhou Y, Lee M, Guo L, Han W, Mo W, Cao WM, Sun D, Xie R, Huang Y. Li J, et al. Among authors: guo l. Nucleic Acids Res. 2018 Apr 6;46(6):2883-2900. doi: 10.1093/nar/gky063. Nucleic Acids Res. 2018. PMID: 29394393 Free PMC article.

10

p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao WM, Dashwood R, Han L, Zhou Y, Dong WG, Huang Y. Zhang J, et al. Among authors: guo l. Oncogene. 2019 Mar;38(11):1905-1919. doi: 10.1038/s41388-018-0524-5. Epub 2018 Nov 2. Oncogene. 2019. PMID: 30390073 Free PMC article.

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