Silvennoinen O - Search Results

1

JAK inhibitor selectivity: new opportunities, better drugs?

Virtanen A, Spinelli FR, Telliez JB, O'Shea JJ, Silvennoinen O, Gadina M. Virtanen A, et al. Among authors: silvennoinen o. Nat Rev Rheumatol. 2024 Oct;20(10):649-665. doi: 10.1038/s41584-024-01153-1. Epub 2024 Sep 9. Nat Rev Rheumatol. 2024. PMID: 39251770 Review.

2

Editorial: JAK inhibition in autoimmune and inflammatory diseases.

Telliez JB, Gadina M, Ghoreschi K, Silvennoinen O, Spinelli FR. Telliez JB, et al. Among authors: silvennoinen o. Front Immunol. 2022 Dec 28;13:1120281. doi: 10.3389/fimmu.2022.1120281. eCollection 2022. Front Immunol. 2022. PMID: 36643918 Free PMC article. No abstract available.

3

Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling.

Virtanen A, Palmroth M, Liukkonen S, Kurttila A, Haikarainen T, Isomäki P, Silvennoinen O. Virtanen A, et al. Among authors: silvennoinen o. Arthritis Rheumatol. 2023 Nov;75(11):2054-2061. doi: 10.1002/art.42547. Epub 2023 Aug 3. Arthritis Rheumatol. 2023. PMID: 37134144

4

Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening.

Pölläniemi A, Virtanen A, Silvennoinen O, Haikarainen T. Pölläniemi A, et al. Among authors: silvennoinen o. SLAS Discov. 2023 Jun;28(4):180-187. doi: 10.1016/j.slasd.2023.05.001. Epub 2023 May 5. SLAS Discov. 2023. PMID: 37149038 Free article.

5

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.

Arwood ML, Liu Y, Harkins SK, Weinstock DM, Yang L, Stevenson KE, Plana OD, Dong J, Cirka H, Jones KL, Virtanen AT, Gupta DG, Ceas A, Lawney B, Yoda A, Leahy C, Hao M, He Z, Choi HG, Wang Y, Silvennoinen O, Hubbard SR, Zhang T, Gray NS, Li LS. Arwood ML, et al. Among authors: silvennoinen o. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. Epub 2023 Jun 7. Cell Chem Biol. 2023. PMID: 37290440 Free PMC article.

6

Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.

Miao Y, Virtanen A, Zmajkovic J, Hilpert M, Skoda RC, Silvennoinen O, Haikarainen T. Miao Y, et al. Among authors: silvennoinen o. J Med Chem. 2024 Jun 27;67(12):10012-10024. doi: 10.1021/acs.jmedchem.4c00197. Epub 2024 Jun 6. J Med Chem. 2024. PMID: 38843875 Free PMC article.

7

Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target.

Virtanen A, Kettunen V, Musta K, Räkköläinen V, Knapp S, Haikarainen T, Silvennoinen O. Virtanen A, et al. Among authors: silvennoinen o. Adv Biol Regul. 2024 Dec 24:101072. doi: 10.1016/j.jbior.2024.101072. Online ahead of print. Adv Biol Regul. 2024. PMID: 39755448 Free article.

8

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

9

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Sep 16;14(1):21579. doi: 10.1038/s41598-024-70321-w. Sci Rep. 2024. PMID: 39284864 Free PMC article. No abstract available.

10

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.

Abraham BG, Haikarainen T, Vuorio J, Girych M, Virtanen AT, Kurttila A, Karathanasis C, Heilemann M, Sharma V, Vattulainen I, Silvennoinen O. Abraham BG, et al. Among authors: silvennoinen o. Sci Adv. 2024 Mar 8;10(10):eadl2097. doi: 10.1126/sciadv.adl2097. Epub 2024 Mar 8. Sci Adv. 2024. PMID: 38457493 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

161 results

Search Page

Filters