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JAK inhibitor selectivity: new opportunities, better drugs?
Virtanen A, Spinelli FR, Telliez JB, O'Shea JJ, Silvennoinen O, Gadina M. Virtanen A, et al. Nat Rev Rheumatol. 2024 Oct;20(10):649-665. doi: 10.1038/s41584-024-01153-1. Epub 2024 Sep 9. Nat Rev Rheumatol. 2024. PMID: 39251770 Review.
Nucleotide-binding mechanisms in pseudokinases.
Hammarén HM, Virtanen AT, Silvennoinen O. Hammarén HM, et al. Biosci Rep. 2015 Nov 20;36(1):e00282. doi: 10.1042/BSR20150226. Biosci Rep. 2015. PMID: 26589967 Free PMC article. Review.
Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response.
Palmroth M, Kuuliala K, Peltomaa R, Virtanen A, Kuuliala A, Kurttila A, Kinnunen A, Leirisalo-Repo M, Silvennoinen O, Isomäki P. Palmroth M, et al. Among authors: virtanen a. Front Immunol. 2021 Sep 24;12:738481. doi: 10.3389/fimmu.2021.738481. eCollection 2021. Front Immunol. 2021. PMID: 34630419 Free PMC article.
Aiming for the pocket.
Silvennoinen O, Haikarainen T, Virtanen A. Silvennoinen O, et al. Among authors: virtanen a. Nat Chem Biol. 2022 Dec;18(12):1296-1297. doi: 10.1038/s41589-022-01120-5. Nat Chem Biol. 2022. PMID: 36097296 No abstract available.
Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response.
Valli A, Kuuliala K, Virtanen A, Kuuliala A, Palmroth M, Peltomaa R, Vidqvist KL, Leirisalo-Repo M, Silvennoinen O, Isomäki P. Valli A, et al. Among authors: virtanen a. Clin Exp Immunol. 2022 Dec 15;210(2):141-150. doi: 10.1093/cei/uxac085. Clin Exp Immunol. 2022. PMID: 36124688 Free PMC article.
307 results