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DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs.
Ohara M, Nagata T, Hara RI, Yoshida-Tanaka K, Toide N, Takagi K, Sato K, Takenaka T, Nakakariya M, Miyata K, Maeda Y, Toh K, Wada T, Yokota T. Ohara M, et al. Among authors: miyata k. Mol Ther Nucleic Acids. 2024 Jul 31;35(3):102289. doi: 10.1016/j.omtn.2024.102289. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39252874 Free PMC article.
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T. Nagata T, et al. Among authors: miyata k, miyata h. Nat Biotechnol. 2021 Dec;39(12):1529-1536. doi: 10.1038/s41587-021-00972-x. Epub 2021 Aug 12. Nat Biotechnol. 2021. PMID: 34385691
Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.
Goto A, Yamamoto S, Igari T, Matsumoto SI, Chisaki I, Iida K, Nakayama M, Oda A, Kakoi Y, Uchida A, Miyata K, Nishikawa M, Nagata T, Kusuhara H, Yokota T, Hirabayashi H. Goto A, et al. Among authors: miyata k. J Pharmacol Exp Ther. 2023 Jan;384(1):197-204. doi: 10.1124/jpet.122.001331. Epub 2022 Oct 23. J Pharmacol Exp Ther. 2023. PMID: 36273821
Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles.
Sugo T, Terada M, Oikawa T, Miyata K, Nishimura S, Kenjo E, Ogasawara-Shimizu M, Makita Y, Imaichi S, Murata S, Otake K, Kikuchi K, Teratani M, Masuda Y, Kamei T, Takagahara S, Ikeda S, Ohtaki T, Matsumoto H. Sugo T, et al. Among authors: miyata k. J Control Release. 2016 Sep 10;237:1-13. doi: 10.1016/j.jconrel.2016.06.036. Epub 2016 Jun 29. J Control Release. 2016. PMID: 27369865
Prevalence and Clinical Outcomes of Discordant Lesions Between Fractional Flow Reserve and Nonhyperemic Pressure Ratios in Clinical Practice: The J-PRIDE Registry.
Kuramitsu S, Kawase Y, Shinozaki T, Domei T, Yamanaka F, Kaneko U, Kakuta T, Horie K, Terai H, Ando H, Shiono Y, Tagashira T, Nogi K, Kubo T, Asano T, Shiraishi J, Otake H, Sugano A, Anai R, Iwai A, Kikuta Y, Nishina H, Fujita T, Amano T, Iwabuchi M, Yokoi H, Akasaka T, Matsuo H, Tanaka N; J-PRIDE Investigators. Kuramitsu S, et al. Circulation. 2025 Jan 9. doi: 10.1161/CIRCULATIONAHA.124.071139. Online ahead of print. Circulation. 2025. PMID: 39781739
Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy.
Sato M, Torigoe D, Kinoshita Y, Cyuman M, Toda C, Sato M, Ikeda K, Kadomatsu T, Horiguchi H, Morinaga J, Fukami H, Sugizaki T, Miyata K, Kusaba R, Okadome Y, Matsunaga E, Node K, Oike Y. Sato M, et al. Among authors: miyata k. NPJ Aging. 2025 Jan 8;11(1):1. doi: 10.1038/s41514-024-00191-z. NPJ Aging. 2025. PMID: 39779757 Free PMC article.
1,874 results