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DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs.
Ohara M, Nagata T, Hara RI, Yoshida-Tanaka K, Toide N, Takagi K, Sato K, Takenaka T, Nakakariya M, Miyata K, Maeda Y, Toh K, Wada T, Yokota T. Ohara M, et al. Among authors: wada t. Mol Ther Nucleic Acids. 2024 Jul 31;35(3):102289. doi: 10.1016/j.omtn.2024.102289. eCollection 2024 Sep 10. Mol Ther Nucleic Acids. 2024. PMID: 39252874 Free PMC article.
Highly efficient silencing of microRNA by heteroduplex oligonucleotides.
Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T. Yoshioka K, et al. Among authors: wada t. Nucleic Acids Res. 2019 Aug 22;47(14):7321-7332. doi: 10.1093/nar/gkz492. Nucleic Acids Res. 2019. PMID: 31214713 Free PMC article.
Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol.
Nishina T, Numata J, Nishina K, Yoshida-Tanaka K, Nitta K, Piao W, Iwata R, Ito S, Kuwahara H, Wada T, Mizusawa H, Yokota T. Nishina T, et al. Among authors: wada t. Mol Ther Nucleic Acids. 2015 Jan 13;4(1):e220. doi: 10.1038/mtna.2014.72. Mol Ther Nucleic Acids. 2015. PMID: 25584900 Free PMC article.
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T. Nagata T, et al. Among authors: wada t. Nat Biotechnol. 2021 Dec;39(12):1529-1536. doi: 10.1038/s41587-021-00972-x. Epub 2021 Aug 12. Nat Biotechnol. 2021. PMID: 34385691
4,591 results