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Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease.
Izquierdo-Altarejos P, Arenas YM, Martínez-García M, Vázquez L, Mincheva G, Doverskog M, Blackburn TP, Bohnen NI, Llansola M, Felipo V. Izquierdo-Altarejos P, et al. Among authors: blackburn tp. Front Aging Neurosci. 2024 Jun 21;16:1417938. doi: 10.3389/fnagi.2024.1417938. eCollection 2024. Front Aging Neurosci. 2024. PMID: 38974902 Free PMC article.
Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.
Mincheva G, Gimenez-Garzo C, Izquierdo-Altarejos P, Martinez-Garcia M, Doverskog M, Blackburn TP, Hällgren A, Bäckström T, Llansola M, Felipo V. Mincheva G, et al. Among authors: blackburn tp. CNS Neurosci Ther. 2022 Nov;28(11):1861-1874. doi: 10.1111/cns.13926. Epub 2022 Jul 26. CNS Neurosci Ther. 2022. PMID: 35880480 Free PMC article.
In memory of Norman Bowery (1944-2016).
Trist DG, Kenakin TP, Blackburn TP. Trist DG, et al. Among authors: blackburn tp. Curr Opin Pharmacol. 2017 Aug;35:89-93. doi: 10.1016/j.coph.2017.05.008. Epub 2017 Aug 29. Curr Opin Pharmacol. 2017. PMID: 28864032
80 results