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Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones.
Eur J Med Chem. 2024 Dec 5;279:116849. doi: 10.1016/j.ejmech.2024.116849. Epub 2024 Sep 5.
Eur J Med Chem. 2024.
PMID: 39265253
Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones.
Joch M, Wojtas KP, Torres-Gómez H, Li Y, Meyer F, Straßburger M, Kerndl V, Dahse HM, Hertweck C, Hoffmann H, Görls H, Walter K, Hölscher C, Kloss F.
Joch M, et al. Among authors: kerndl v.
Eur J Med Chem. 2024 Jan 15;264:116023. doi: 10.1016/j.ejmech.2023.116023. Epub 2023 Dec 3.
Eur J Med Chem. 2024.
PMID: 38071794
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