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Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O. Garscha U, et al. Among authors: werz o. Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w. Sci Rep. 2017. PMID: 28839250 Free PMC article.
Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
Cheung SY, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S. Cheung SY, et al. Among authors: werz o. Eur J Med Chem. 2018 Aug 5;156:815-830. doi: 10.1016/j.ejmech.2018.07.031. Epub 2018 Jul 25. Eur J Med Chem. 2018. PMID: 30053720
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.
Werner M, Jordan PM, Romp E, Czapka A, Rao Z, Kretzer C, Koeberle A, Garscha U, Pace S, Claesson HE, Serhan CN, Werz O, Gerstmeier J. Werner M, et al. Among authors: werz o. FASEB J. 2019 May;33(5):6140-6153. doi: 10.1096/fj.201802509R. Epub 2019 Feb 8. FASEB J. 2019. PMID: 30735438 Free PMC article.
M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H.-E., Serhan, C. N., Werz, O., Gerstmeier, J. Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome....
M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H.-E., Serhan, C. N., Werz, O., …
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O. König S, et al. Among authors: werz o. Cell Chem Biol. 2019 Apr 18;26(4):524-534.e5. doi: 10.1016/j.chembiol.2019.01.001. Epub 2019 Feb 7. Cell Chem Biol. 2019. PMID: 30745237 Free article.
Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.
Rao Z, Pace S, Jordan PM, Bilancia R, Troisi F, Börner F, Andreas N, Kamradt T, Menche D, Rossi A, Serhan CN, Gerstmeier J, Werz O. Rao Z, et al. Among authors: werz o. J Immunol. 2019 Aug 15;203(4):1031-1043. doi: 10.4049/jimmunol.1900236. Epub 2019 Jul 12. J Immunol. 2019. PMID: 31300512 Free PMC article.
420 results