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A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner.
Boltz TA, Chu BB, Liao C, Sealock JM, Ye R, Majara L, Fu JM, Service S, Zhan L, Medland SE, Chapman SB, Rubinacci S, DeFelice M, Grimsby JL, Abebe T, Alemayehu M, Ashaba FK, Atkinson EG, Bigdeli T, Bradway AB, Brand H, Chibnik LB, Fekadu A, Gatzen M, Gelaye B, Gichuru S, Gildea ML, Hill TC, Huang H, Hubbard KM, Injera WE, James R, Joloba M, Kachulis C, Kalmbach PR, Kamulegeya R, Kigen G, Kim S, Koen N, Kwobah EK, Kyebuzibwa J, Lee S, Lennon NJ, Lind PA, Lopera-Maya EA, Makale J, Mangul S, McMahon J, Mowlem P, Musinguzi H, Mwema RM, Nakasujja N, Newman CP, Nkambule LL, O'Neil CR, Olivares AM, Olsen CM, Ongeri L, Parsa SJ, Pretorius A, Ramesar R, Reagan FL, Sabatti C, Schneider JA, Shiferaw W, Stevenson A, Stricker E, Stroud RE 2nd, Tang J, Whiteman D, Yohannes MT, Yu M, Yuan K; NeuroGAP-Psychosis; Akena D, Atwoli L, Kariuki SM, Koenen KC, Newton CRJC, Stein DJ, Teferra S, Zingela Z, Pato CN, Pato MT, Lopez-Jaramillo C, Freimer N, Ophoff RA, Olde Loohuis LM, Talkowski ME, Neale BM, Howrigan DP, Martin AR. Boltz TA, et al. Among authors: yuan k. bioRxiv [Preprint]. 2024 Sep 8:2024.09.06.611689. doi: 10.1101/2024.09.06.611689. bioRxiv. 2024. PMID: 39282356 Free PMC article. Preprint.
Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases.
Yuan K, Longchamps RJ, Pardiñas AF, Yu M, Chen TT, Lin SC, Chen Y, Lam M, Liu R, Xia Y, Guo Z, Shi W, Shen C; Schizophrenia Workgroup of Psychiatric Genomics Consortium; Daly MJ, Neale BM, Feng YA, Lin YF, Chen CY, O'Donovan M, Ge T, Huang H. Yuan K, et al. medRxiv [Preprint]. 2023 Jul 9:2023.01.07.23284293. doi: 10.1101/2023.01.07.23284293. medRxiv. 2023. Update in: Nat Genet. 2024 Sep;56(9):1841-1850. doi: 10.1038/s41588-024-01870-z PMID: 36711496 Free PMC article. Updated. Preprint.
Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases.
Yuan K, Longchamps RJ, Pardiñas AF, Yu M, Chen TT, Lin SC, Chen Y, Lam M, Liu R, Xia Y, Guo Z, Shi W, Shen C; Schizophrenia Workgroup of Psychiatric Genomics Consortium; Daly MJ, Neale BM, Feng YA, Lin YF, Chen CY, O'Donovan MC, Ge T, Huang H. Yuan K, et al. Nat Genet. 2024 Sep;56(9):1841-1850. doi: 10.1038/s41588-024-01870-z. Epub 2024 Aug 26. Nat Genet. 2024. PMID: 39187616
Cross-ancestry analysis of brain QTLs enhances interpretation of schizophrenia genome-wide association studies.
Chen Y, Liu S, Ren Z, Wang F, Liang Q, Jiang Y, Dai R, Duan F, Han C, Ning Z, Xia Y, Li M, Yuan K, Qiu W, Yan XX, Dai J, Kopp RF, Huang J, Xu S, Tang B, Wu L, Gamazon ER, Bigdeli T, Gershon E, Huang H, Ma C, Liu C, Chen C. Chen Y, et al. Among authors: yuan k. Am J Hum Genet. 2024 Nov 7;111(11):2444-2457. doi: 10.1016/j.ajhg.2024.09.001. Epub 2024 Oct 2. Am J Hum Genet. 2024. PMID: 39362218 Free PMC article.
Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals.
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Zhou H, et al. Among authors: yuan k. medRxiv [Preprint]. 2023 Jan 30:2023.01.24.23284960. doi: 10.1101/2023.01.24.23284960. medRxiv. 2023. Update in: Nat Med. 2023 Dec;29(12):3184-3192. doi: 10.1038/s41591-023-02653-5 PMID: 36747741 Free PMC article. Updated. Preprint.
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.
Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Zhou H, et al. Among authors: yuan k. Nat Med. 2023 Dec;29(12):3184-3192. doi: 10.1038/s41591-023-02653-5. Epub 2023 Dec 7. Nat Med. 2023. PMID: 38062264 Free PMC article.
2,524 results