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Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease.
de Groot R, Folgado PB, Yamamoto K, Martin DR, Koch CD, Debruin D, Blagg S, Minns AF, Bhutada S, Ahnström J, Larkin J, Aspberg A, Önnerfjord P, Apte SS, Santamaria S. de Groot R, et al. Among authors: bhutada s. Matrix Biol. 2025 Feb;135:106-124. doi: 10.1016/j.matbio.2024.12.005. Epub 2024 Dec 11. Matrix Biol. 2025. PMID: 39672391 Free article.
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.
Mead TJ, Bhutada S, Foulcer SJ, Peruzzi N, Nelson CM, Seifert DE, Larkin J, Tran-Lundmark K, Filmus J, Apte SS. Mead TJ, et al. Among authors: bhutada s. Matrix Biol. 2024 Aug;131:1-16. doi: 10.1016/j.matbio.2024.05.003. Epub 2024 May 13. Matrix Biol. 2024. PMID: 38750698 Free PMC article.
Consequences of PDGFRα+ fibroblast reduction in adult murine hearts.
Kuwabara JT, Hara A, Bhutada S, Gojanovich GS, Chen J, Hokutan K, Shettigar V, Lee AY, DeAngelo LP, Heckl JR, Jahansooz JR, Tacdol DK, Ziolo MT, Apte SS, Tallquist MD. Kuwabara JT, et al. Among authors: bhutada s. Elife. 2022 Sep 23;11:e69854. doi: 10.7554/eLife.69854. Elife. 2022. PMID: 36149056 Free PMC article.
Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation.
Kuwabara JT, Hara A, Heckl JR, Peña B, Bhutada S, DeMaris R, Ivey MJ, DeAngelo LP, Liu X, Park J, Jahansooz JR, Mestroni L, McKinsey TA, Apte SS, Tallquist MD. Kuwabara JT, et al. Among authors: bhutada s. J Mol Cell Cardiol. 2022 Aug;169:84-95. doi: 10.1016/j.yjmcc.2022.05.003. Epub 2022 May 13. J Mol Cell Cardiol. 2022. PMID: 35569524 Free PMC article.
19 results