Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.
Al-Azzam N, To JH, Gautam V, Street LA, Nguyen CB, Naritomi JT, Lam DC, Madrigal AA, Lee B, Jin W, Avina A, Mizrahi O, Mueller JR, Ford W, Schiavon CR, Rebollo E, Vu AQ, Blue SM, Madakamutil YL, Manor U, Rothstein JD, Coyne AN, Jovanovic M, Yeo GW.
Al-Azzam N, et al. Among authors: lam dc.
Neuron. 2024 Oct 31:S0896-6273(24)00728-1. doi: 10.1016/j.neuron.2024.10.007. Online ahead of print.
Neuron. 2024.
PMID: 39486415
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