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Page 1
Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis.
David T, Šedinová M, Myšková A, Kuneš J, Maletínská L, Pohl R, Dračínský M, Mertlíková-Kaiserová H, Čížek K, Klepetářová B, Litecká M, Kaňa A, Sýkora D, Jaroš A, Straka M, Polasek M. David T, et al. Among authors: mertlikova kaiserova h. Nat Commun. 2024 Nov 13;15(1):9836. doi: 10.1038/s41467-024-53867-1. Nat Commun. 2024. PMID: 39537622 Free PMC article.
Sulfonated Hydroxyaryl-Tetrazines with Increased pKa for Accelerated Bioorthogonal Click-to-Release Reactions in Cells.
Rahm M, Keppel P, Šlachtová V, Dzijak R, Dračínský M, Bellová S, Reyes-Gutiérrez PE, Štěpánová S, Raffler J, Tloušťová E, Mertlíková-Kaiserová H, Mikula H, Vrabel M. Rahm M, et al. Among authors: mertlikova kaiserova h. Angew Chem Int Ed Engl. 2024 Sep 19:e202411713. doi: 10.1002/anie.202411713. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39298292
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
Kocek H, Chalupská D, Dejmek M, Dvořáková A, Zgarbová M, Šála M, Chalupský K, Krafčíková P, Otava T, Drexler M, Procházková E, Klepetářová B, Štefek M, Kozic J, Mertlíková-Kaiserová H, Boura E, Weber J, Nencka R. Kocek H, et al. Among authors: mertlikova kaiserova h. RSC Med Chem. 2024 Aug 1;15(10):3469-76. doi: 10.1039/d4md00422a. Online ahead of print. RSC Med Chem. 2024. PMID: 39220762 Free PMC article.
Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine.
Chayka A, Česnek M, Kužmová E, Kozák J, Tloušt'ová E, Dvořáková A, Strmeň T, Brož B, Osifová Z, Dračínský M, Mertlíková-Kaiserová H, Janeba Z. Chayka A, et al. Among authors: mertlikova kaiserova h. J Med Chem. 2024 Jun 27;67(12):10135-10151. doi: 10.1021/acs.jmedchem.4c00323. Epub 2024 Jun 10. J Med Chem. 2024. PMID: 38857067 Free PMC article.
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
Spiwoková P, Horn M, Fanfrlík J, Jílková A, Fajtová P, Leontovyč A, Houštecká R, Bieliková L, Brynda J, Chanová M, Mertlíková-Kaiserová H, Caro-Diaz EJE, Almaliti J, El-Sakkary N, Gerwick WH, Caffrey CR, Mareš M. Spiwoková P, et al. Among authors: mertlikova kaiserova h. ACS Infect Dis. 2024 Jun 14;10(6):1935-1948. doi: 10.1021/acsinfecdis.3c00589. Epub 2024 May 17. ACS Infect Dis. 2024. PMID: 38757505 Free PMC article.
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors.
Misehe M, Šála M, Matoušová M, Hercík K, Kocek H, Chalupská D, Chaloupecká E, Hájek M, Boura E, Mertlíková-Kaiserová H, Nencka R. Misehe M, et al. Among authors: mertlikova kaiserova h. Bioorg Med Chem Lett. 2024 Jan 1;97:129567. doi: 10.1016/j.bmcl.2023.129567. Epub 2023 Nov 24. Bioorg Med Chem Lett. 2024. PMID: 38008339 Free article.
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
Misehe M, Matoušová M, Dvořáková A, Hercík K, Škach K, Chalupská D, Dejmek M, Šála M, Hájek M, Boura E, Mertlíková-Kaiserová H, Nencka R. Misehe M, et al. Among authors: mertlikova kaiserova h. Eur J Med Chem. 2023 Nov 15;260:115717. doi: 10.1016/j.ejmech.2023.115717. Epub 2023 Aug 9. Eur J Med Chem. 2023. PMID: 37598483 Free article.
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
Štefek M, Chalupská D, Chalupský K, Zgarbová M, Dvořáková A, Krafčíková P, Li ASM, Šála M, Dejmek M, Otava T, Chaloupecká E, Kozák J, Kozic J, Vedadi M, Weber J, Mertlíková-Kaiserová H, Nencka R. Štefek M, et al. Among authors: mertlikova kaiserova h. ACS Omega. 2023 Jul 21;8(30):27410-27418. doi: 10.1021/acsomega.3c02815. eCollection 2023 Aug 1. ACS Omega. 2023. PMID: 37546609 Free PMC article.
48 results