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Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells.
Hieber C, Mustafa AM, Neuroth S, Henninger S, Wollscheid HP, Zabkiewicz J, Lazenby M, Alvares C, Mahboobi S, Butter F, Brenner W, Bros M, Krämer OH. Hieber C, et al. Among authors: lazenby m. Biomed Pharmacother. 2024 Aug;177:117076. doi: 10.1016/j.biopha.2024.117076. Epub 2024 Jul 5. Biomed Pharmacother. 2024. PMID: 38971011 Free article.
Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia.
Zabkiewicz J, Lazenby M, Edwards G, Bygrave CA, Omidvar N, Zhuang L, Knapper S, Guy C, Hills RK, Burnett AK, Alvares CL. Zabkiewicz J, et al. Among authors: lazenby m. Br J Haematol. 2020 Oct;191(2):231-242. doi: 10.1111/bjh.16665. Epub 2020 May 11. Br J Haematol. 2020. PMID: 32394450 Free article.
75 results