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HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.
Contreras RE, Gruber T, González-García I, Schriever SC, De Angelis M, Mallet N, Bernecker M, Legutko B, Kabra D, Schmidt M, Tschöp MH, Gutierrez-Aguilar R, Mellor J, García-Cáceres C, Pfluger PT. Contreras RE, et al. Among authors: de angelis m. Mol Metab. 2024 Dec;90:102033. doi: 10.1016/j.molmet.2024.102033. Epub 2024 Sep 19. Mol Metab. 2024. PMID: 39304061 Free PMC article.
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.
Maity-Kumar G, Ständer L, DeAngelis M, Lee S, Molenaar A, Becker L, Garrett L, Amerie OV, Hoelter SM, Wurst W, Fuchs H, Feuchtinger A, Gailus-Durner V, Garcia-Caceres C, Othman AE, Brockmann C, Schöffling VI, Beiser K, Krude H, Mroz PA, Hofmann S, Tuckermann J, DiMarchi RD, Hrabe de Angelis M, Tschöp MH, Pfluger PT, Müller TD. Maity-Kumar G, et al. Mol Metab. 2022 Dec;66:101616. doi: 10.1016/j.molmet.2022.101616. Epub 2022 Oct 18. Mol Metab. 2022. PMID: 36270613 Free PMC article.
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT. Pfuhlmann K, et al. Among authors: de angelis m. Diabetes. 2018 Nov;67(11):2456-2465. doi: 10.2337/db18-0146. Epub 2018 Aug 28. Diabetes. 2018. PMID: 30158241
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, Martinez S, Wu M, Häring HU, de Angelis MH, Beckers J, Müller TD, Stemmer K, Wurst W, Rozman J, Nogueiras R, De Angelis M, Molkentin JD, Krahmer N, Yi CX, Schmidt MV, Luquet S, Heni M, Tschöp MH, Pfluger PT. Schriever SC, et al. Among authors: de angelis m, de angelis mh. J Clin Invest. 2020 Nov 2;130(11):6093-6108. doi: 10.1172/JCI136363. J Clin Invest. 2020. PMID: 32780722 Free PMC article.
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC. Kyriakou E, et al. Among authors: de angelis m. J Med Chem. 2018 Dec 27;61(24):11144-11157. doi: 10.1021/acs.jmedchem.8b01224. Epub 2018 Dec 7. J Med Chem. 2018. PMID: 30525586
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.
Jall S, De Angelis M, Lundsgaard AM, Fritzen AM, Nicolaisen TS, Klein AB, Novikoff A, Sachs S, Richter EA, Kiens B, Schramm KW, Tschöp MH, Stemmer K, Clemmensen C, Müller TD, Kleinert M. Jall S, et al. Among authors: de angelis m. Diabetologia. 2020 Jun;63(6):1236-1247. doi: 10.1007/s00125-020-05117-4. Epub 2020 Mar 6. Diabetologia. 2020. PMID: 32140744 Free PMC article.
1,427 results